Worse outcome of debridement, antibiotics, and implant retention in acute hematogenous infections than in postsurgical infections after total knee arthroplasty: a multicenter study
Knee Surgery & Related Research volume 34, Article number: 38 (2022)
We sought to determine (1) the success rate of debridement, antibiotics, and implant retention (DAIR) for acute periprosthetic joint infection (PJI) of the knee in patients with acute postsurgical infection and in those with acute hematogenous infection via a multicenter study, (2) the factors related to the failure of DAIR for overall acute PJI and acute hematogenous PJI via subgroup analysis, and (3) whether the PJI recurrence patterns differed between the two groups over time after DAIR.
This retrospective multicenter study included 101 acute knee PJI. Acute postsurgical PJI was defined as PJI diagnosed < 3 months following initial knee arthroplasty surgery. DAIR was performed for 34 cases of acute postsurgical PJIs (postsurgical group) and 67 cases of acute hematogenous PJIs (hematogenous group). The success rates between groups were compared, and factors related to DAIR failure were analyzed.
The overall success rate of DAIR was 77%. The success rate tended to be higher in the postsurgical group than in the hematogenous group (p = 0.060). However, there was no significant factor related to DAIR failure in the subgroup analysis of acute hematogenous PJIs. In the postsurgical group, the recurrence of PJI occurred until 3 months, whereas in the hematogenous group, recurrence occurred for up to 2 years.
The failure rate tended to be higher in the acute hematogenous PJI group than in the acute postsurgical PJI group. Since acute hematogenous infections may recur for a longer period than postsurgical infections, careful follow-up is required after DAIR.
Periprosthetic joint infections (PJIs) are one of the most serious complications after total knee arthroplasty (TKA) [1,2,3,4]). In the early stage of a PJI, debridement, antibiotics, and implant retention (DAIR) may be useful surgical options [5, 6]. If a PJI can be treated using DAIR, this can substantially reduce the surgical morbidity of the patient . However, the existing success rate of DAIR ranges widely from 16% to 82% [8, 9]. Furthermore, a previous study revealed that failed prior DAIR could lead to an increased failure rate of subsequent two-stage revision arthroplasty . Therefore, DAIR should be used for reasonable indications.
Despite the improvements in surgical techniques and patient care, the success rate of DAIR has not improved significantly . Although the indications or guidelines for DAIR have not yet been clearly established, patient selection is probably the most important factor for the success of DAIR [12,13,14]. For patient selection, surgeons need to understand the factors related to DAIR failure. Patient age, immune status, obesity, and comorbid diseases are all likely to be involved but the impact of these factors has been inconsistently reported depending upon the study [12, 14,15,16]. Recently, it was revealed that the rate of DAIR failure in acute hematogenous PJI was almost two times higher than that in acute postsurgical PJI . In acute postsurgical PJI, it is reasonable that DAIR should be selected as the first treatment method because it is clear when the infection began. However, a different surgical strategy is probably needed for acute hematogenous PJI according to the patients’ conditions. In addition, sometimes it is not clear when the infection started in acute hematogenous PJI. If postsurgical and hematogenous PJIs have different characteristics, the factors related to DAIR failure may be different for acute postsurgical and acute hematogenous PJIs. However, most previous studies included both acute postsurgical and acute hematogenous PJIs in the same category of acute infections for analyzing the factors related to DAIR failure.
Therefore, we sought to determine (1) the success rate of DAIR for acute PJI of the knee in patients with acute postsurgical and acute hematogenous infections using a multicenter study, (2) the factors related to the failure of DAIR for overall acute PJI and acute hematogenous PJI using subgroup analysis, and (3) whether the PJI recurrence patterns differed between acute postsurgical and acute hematogenous PJIs over time after DAIR. We hypothesized that the DAIR failure rate would be higher in acute hematogenous PJI than in acute postsurgical PJI. We also hypothesized that the risk factors associated with DAIR failure and the recurrence patterns would differ between acute postsurgical and acute hematogenous PJIs.
This retrospective multicenter study included 101 knees (95 patients) from three referral hospitals between July 2005 and November 2019. The inclusion criteria for this study were as follows: (1) PJI after primary and revision TKA; (2) DAIR with polyethylene insert changes; and (3) acute postsurgical infection and acute hematogenous infection within 4 weeks of the onset of symptoms. 102 cases were found using all criteria 1, 2, and 3 of PJIs were identified via review of medical records. Before 2011, PJI was diagnosed using various criteria, and after 2011, it was diagnosed using Musculoskeletal Infection Society (MSIS) PJI diagnosis criteria [18, 19]. Among these cases, 36 PJIs were diagnosed before 2011. For cases diagnosed before 2011, only patients who could be diagnosed with PJI were included by applying the 2011 MSIS criteria retrospectively. Finally, 101 knees were included in this study after excluding 1 case of PJI that did not meet MSIS criteria. The patients were classified as having acute postsurgical PJI if the PJI was diagnosed < 3 months following the initial knee arthroplasty surgery. An acute hematogenous infection was defined as PJI diagnosed after more than 3 months had passed following the index arthroplasty . Patients with revision arthroplasty were also included in the study, but only if they had aseptic conditions before revision surgery, determined via laboratory tests, joint aspiration, and intraoperative cultures. To include only patients defined as having acute infections, patients with DAIR for an uncertain duration of symptoms were excluded. There were 81 female and 14 male patients with a mean age of 74 years (range 61–86 years). DAIR was performed for 34 cases of acute postsurgical PJI (postsurgical group) and 67 cases of acute hematogenous PJI (hematogenous group) (Table 1). The mean duration of symptoms before DAIR was 6.8 days in the postsurgical group and 8.3 days in the hematogenous group. Average body mass index (BMI) and incidence of diabetes mellitus (DM) were higher in the hematogenous group than in the postsurgical group (58% versus 26%). The protocol of this study was approved by the institutional review board of the three involved hospitals.
All surgeries were performed by seven surgeons in three centers. Even if DAIR techniques were not standardized between centers, all DAIR procedures included polyethylene insert change, complete resection of necrotic soft tissue, and massive irrigation using at least 9 L of saline. The surgical gloves were changed, and new draping was added before the surgical incision was closed. Postoperatively, intravenous antibiotics were administered for 4–6 weeks and then converted to oral antibiotic treatment.
Clinical evaluations were performed by fellowship-trained orthopedic surgeons in the three hospitals using the same methods. The patients were identified in the institutional databases using electronic medical records. Clinical information was collected by manual chart review. Patient demographics [age, sex, body mass index (BMI), Charlson Comorbidity Index (CCI), laterality, index surgery (primary or aseptic revision), Kidney, Liver, Index surgery, Cemented prosthesis and C-reactive protein value (KLIC) score, and DM] were investigated . Symptom duration was defined as the time interval from first symptom onset to day of DAIR. Implant age was defined as the time interval between primary or revision surgery and day of DAIR. Preoperative level of serum C-reactive protein (CRP) was defined as the value checked at the first visit to the hospital for PJI-related symptoms. The causative organisms were classified into eight categories as follows: (1) Staphylococcus aureus, (2) antibiotic-resistant organisms including methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus epidermidis, (3) Streptococcus, (4) Enterococcus, (5) Candida, (6) Gram-negative bacteria, (7) polymicrobial infections, and (8) negative cultures. DAIR failure was defined as a case where repeated DAIR or two-stage revision surgery was performed during the follow-up period. None of the patients included in the current study received chronic antibiotic suppression.
The overall success rate of DAIR and the factors related to DAIR failure were analyzed for both acute postsurgical and hematogenous infections. In addition, the factors related to DAIR failure in the hematogenous group were determined using subgroup analysis. Continuous variables including age, BMI, symptom duration, implant age, and preoperative serum CRP levels were described using mean and standard deviation (SD). Categorical variables including sex, CCI, DM, primary or revision TKA, acute postsurgical or hematogenous PJI, and type of organism were described using number and percentage. To compare demographics between the postsurgical group and the hematogenous group, a Student’s t-test was used for continuous variables and a chi-squared test was used for categorical variables. To determine the factors related to DAIR failure, a logistic regression test was used. Univariate analysis was performed with the independent variables of age, sex, BMI, DM, primary or revision surgery, symptom duration, implant age, preoperative serum CRP level, CCI, and acute postsurgical or hematogenous PJI. Then, multivariate analysis was performed using the variables with a p-value of < 0.2 on univariate analysis. The pattern of recurrence was analyzed using Kaplan–Meier survivorship curves with repeated DAIR or two-stage revision surgery as the endpoints.
The overall success rate of DAIR was 77%. On univariate analysis using the overall patient cohort, the success rate tended to be higher in the postsurgical group than in the hematogenous group (88% versus 72%; p = 0.060). Preoperative serum CRP levels also tended to be higher in the case of DAIR failure (p = 0.082) (Table 2). On multivariate analysis, these two factors did not reach statistical significance. The success rate tended to be higher in the postsurgical group than in the hematogenous group [odds ratio (OR) 2.443; confidence interval (CI) 0.839–8.496; p = 0.104]. In addition, the preoperative serum CRP levels tended to be higher in DAIR failure cases (OR 1.044; CI 0.998–1.094; p = 0.059).
There was no significant factor related to DAIR failure on subgroup analysis of acute hematogenous PJIs. On univariate analysis, only type of causative organism was related to increased DAIR failure (p = 0.035). Patients with antibiotic-resistant organisms and polymicrobial infections showed higher failure rates (Table 3). However, on multivariate analysis, no factor was associated with DAIR failure in the subgroup analysis of acute hematogenous PJIs.
PJI recurrence occurred for a longer period of time after DAIR in the hematogenous group than in the postsurgical group. In the postsurgical group, the recurrence of PJI occurred until 3 months, whereas in the hematogenous group, recurrence occurred for up to 2 years (Fig. 1).
Despite the improvements in surgical techniques and the increased understanding of pathophysiology in PJI, the success rate of DAIR has not improved significantly. For successful DAIR, patient selection is probably the most important factor, and especially in acute hematogenous PJIs, there may be more considerations than for acute postsurgical PJIs. In the present study, the failure rate of DAIR tended to be higher in patients with acute hematogenous PJIs than with acute postsurgical PJIs. Furthermore, on subgroup analysis using only acute hematogenous PJIs, the causative organism was related to increased DAIR failure in the univariate analysis. However, no factor related to DAIR failure in acute hematogenous PJIs was identified on multivariate analysis. In terms of PJI recurrence, there was a case of late recurrence up to 2 years after DAIR in the hematogenous group, which means that closer observation is required for a longer period of time in patients with acute hematogenous PJIs even if it is judged that the hematogenous PJI is successfully controlled.
The differences in DAIR success rates for PJI of the knee between previous studies can be attributed to the heterogeneity of the studies. Previous studies included both hip and knee PJIs or included patients with or without polyethylene insert changes [8, 11]. PJI of the knee is a serious but not common complication, and it occurs in 1–2% of the cases, making prospective studies difficult . Also, the DAIR success rate may depend upon the surgical technique and perioperative management, and these factors may be the reason the surgical results differed between single-center studies [5, 22]. Therefore, research related to the success rate of DAIR should be conducted in a multicenter study with relatively larger numbers of subjects. Although a recent study reported a relatively low DAIR success rate of 64% in patients with early postoperative PJI, other studies reported that it was close to 80% [5, 8]. In our study, the overall success rate was 77%. To increase the success rate of DAIR, studies have reported the factors related to failure, and further studies are needed to determine if substantial improvements in success rates can be obtained in the future.
One of the findings that can be relatively useful in determining whether to perform DAIR surgery is that acute postsurgical PJIs have been reported to have a higher success rate than hematogenous PJIs [8, 17]. It was reported that DAIR was successful in 64% of early PJIs (implant age < 1 year) versus 38% of late hematogenous PJIs (implant age > 1 year; OR 1.78; p = 0.01) . One possible explanation is that the elapsed time from infection to DAIR is one of the important factors in DAIR success, and the duration of symptoms is clearer in acute postsurgical PJIs than in acute hematogenous PJIs. In addition, in hematogenous PJIs, not only is the duration of symptoms ambiguous, but there could also be cases of acute exacerbation by chronic infection. A possible reason for the less clear symptom duration in acute hematogenous PJIs is that the virulence of the causative organism is low, and the symptoms are not severe, so early infection detection may be difficult. However, there was no difference in the causative organisms in the patients in our study. If such a difference is present, there may be cases where severe symptoms do not appear or the patients are not able to recognize them. This may be related to reduced inflammatory responses or pain sensations. These may occur in patients who are chronic users of nonsteroidal anti-inflammatory drugs or pain killers, or in patients with neuropathy. The prevalence of DM of the acute hematogenous PJI group in our study was higher than in the acute postsurgical infection group (58% versus 26%). Whether this was directly related to increased DAIR failure, or whether it delays the time of infection detection owing to other causes such as polyneuropathy, ultimately worsening the outcome of DAIR, needs to be studied further.
It is important to know which factors in patients with hematogenous PJIs are associated with recurrence. It was revealed that Staphylococcus aureus and Gram-negative infections were risk factors for DAIR failure in PJIs with an implant age greater than 1 year . Univariate analysis on subgroup analysis using only hematogenous infections in our study showed similar results, that the causative organism was related to increased DAIR failure in hematogenous PJIs. However, in our study, antibiotic-resistant organisms and polymicrobial infections were associated with DAIR failure. Our findings are supported by a recent study reporting that the presence of DM and polymicrobial infections was related to DAIR failure in acute hematogenous PJIs of hip and knee joints . It is noteworthy that recurrences were not more common in Gram-negative bacteria and fungal PJIs in the present study. Since the number of PJIs caused by these atypical organisms was relatively small, further studies are necessary to confirm these findings.
Our findings support the hypothesis that recurrence patterns differ between acute postsurgical and acute hematogenous PJIs. Xu et al. reported an increased failure of DAIR over time after surgery . In their study, the 1-year failure rate was 41.2% whereas the failure rate at 2 years was 45.9%. Another study comparing the failure rate of DAIR between acute postsurgical and hematogenous PJIs showed that acute hematogenous PJIs had consistent recurrences during a 1-year follow-up period, whereas most acute postsurgical PJIs recurred at an early stage . The present study also showed recurrences of infections for up to 2 years in the hematogenous group, consistent with previous studies. Therefore, continuous and close follow-up including long-term antibiotic suppression is required even if it is judged that the hematogenous PJI is successfully controlled using DAIR .
There were several limitations to this study that should be considered. First, the sample size was relatively small. Since the occurrence of PJI after arthroplasty surgery is rare, even though the study was conducted in a multicenter study, for some variables, only tendencies could be confirmed rather than clear statistical significance identified on subgroup analysis. This needs to be confirmed in further studies with higher numbers of subjects. Second, to include as many patient samples as possible, patients were enrolled over a long period of time, so the PJI diagnostic criteria used in this study were different according to the time period. However, the MSIS criteria were used after 2011. In addition, patients diagnosed with PJI before 2011 were retrospectively confirmed as PJI by applying the same criteria. Third, depending upon each surgeon or hospital, the surgical method may have differed, such as whether betadine scrubbing or soaking was used. In addition, duration of antibiotic treatments was different between patients according to the patients’ conditions and causative organisms. However, this may be an advantage of a multicenter study that reflects real-world practice. In addition, all surgeries were performed following the principles of polyethylene change, thorough debridement of necrotic tissue, and massive irrigation, which are at the core of the DAIR procedure.
The failure rate tended to be higher in the acute hematogenous PJI group compared with the acute postsurgical PJI group, even if no definite factor related to DAIR failure for acute hematogenous PJIs was identified. Since acute hematogenous infections may recur for a longer period after DAIR than postsurgical infections, caution and careful follow-up are required.
Availability of data and materials
Periprosthetic joint infection
Debridement, antibiotics, and implant retention
Total knee arthroplasty
Musculoskeletal Infection Society
Body mass index
Charlson comorbidity index
Kim CW, Lee CR, Park DH, Kim DY, Kim JW (2021) Clinical outcomes of two-stage revision for chronic periprosthetic joint infection of the knee: culture-negative versus culture-positive. Knee Surg Relat Res 33:28
Hoshino T, Watanabe T, Nakagawa Y, Katagiri H, Ozeki N, Ohara T, Shioda M, Kono Y, Sekiya I, Koga H (2021) Clinical outcomes of two-stage revision total knee arthroplasty in infected cases with antibiotic-loaded cement spacers produced using a handmade silicone mold. Knee Surg Relat Res 33:27
Schmitt DR, Killen C, Murphy M, Perry M, Romano J, Brown N (2020) The impact of antibiotic-loaded bone cement on antibiotic resistance in periprosthetic knee infections. Clin Orthop Surg 12:318–323
Rattanaprichavej P, Laoruengthana A, Galassi M, Weerakul S, Rasamimongkol S (2020) Contamination rate of burnt necrotic tissue after electrocoagulation in total knee arthroplasty. Clin Orthop Surg 12:43–48
Vaz K, Scarborough M, Bottomley N, Kendrick B, Taylor A, Price A, Alvand A, Jackson W (2020) Debridement, antibiotics and implant retention (DAIR) for the management of knee prosthetic joint infection. Knee 27:2013–2015
Ottesen CS, Troelsen A, Sandholdt H, Jacobsen S, Husted H, Gromov K (2019) Acceptable success rate in patients with periprosthetic knee joint infection treated with debridement, antibiotics, and implant retention. J Arthroplasty 34:365–368
Iqbal F, Shafiq B, Noor SS, Ali Z, Memon N, Memon N (2020) Economic burden of periprosthetic joint infection following primary total knee replacement in a developing country. Clin Orthop Surg 12:470–476
Zhu MF, Kim K, Cavadino A, Coleman B, Munro JT, Young SW (2021) Success rates of debridement, antibiotics, and implant retention in 230 infected total knee arthroplasties: implications for classification of periprosthetic joint infection. J Arthroplasty 36:305–10.e1
Tözün IR, Ozden VE, Dikmen G, Karaytuğ K (2020) Trends in the treatment of infected knee arthroplasty. EFORT Open Rev 5:672–683
Sherrell JC, Fehring TK, Odum S, Hansen E, Zmistowski B, Dennos A, Kalore N (2011) The Chitranjan Ranawat Award: fate of two-stage reimplantation after failed irrigation and débridement for periprosthetic knee infection. Clin Orthop Relat Res 469:18–25
Xu C, Goswami K, Li WT, Tan TL, Yayac M, Wang SH, Parvizi J (2020) Is treatment of periprosthetic joint infection improving over time? J Arthroplasty 35:1696–702.e1
Katakam A, Melnic CM, Bedair HS (2020) Morbid obesity is a risk factor for infection recurrence following debridement, antibiotics, and implant retention for periprosthetic joint infection. J Arthroplasty 35:3710–3715
Iza K, Foruria X, Moreta J, Uriarte I, Loroño A, Aguirre U, de Los Mozos JLM (2019) DAIR (debridement, antibiotics and implant retention) less effective in hematogenous total knee arthroplasty infections. J Orthop Surg Res 14:278
Hersh BL, Shah NB, Rothenberger SD, Zlotnicki JP, Klatt BA, Urish KL (2019) Do culture negative periprosthetic joint infections remain culture negative? J Arthroplasty 34:2757–2762
Rudelli BA, Giglio PN, de Carvalho VC, Pécora JR, Gurgel HMC, Gobbi RG, Vicente JRN, Lima A, Helito CP (2020) Bacteria drug resistance profile affects knee and hip periprosthetic joint infection outcome with debridement, antibiotics and implant retention. BMC Musculoskelet Disord 21:574
Jacobs AME, Valkering LJJ, Bénard M, Meis JF, Goosen JHM (2019) Evaluation one year after DAIR treatment in 91 suspected early prosthetic joint infections in primary knee and hip arthroplasty. J Bone Jt Infect 4:238–244
Shohat N, Goswami K, Tan TL, Fillingham Y, Parvizi J (2019) Increased failure after irrigation and debridement for acute hematogenous periprosthetic joint infection. J Bone Jt Surg Am 101:696–703
Parvizi J, Zmistowski B, Berbari EF, Bauer TW, Springer BD, Della Valle CJ, Garvin KL, Mont MA, Wongworawat MD, Zalavras CG (2011) New definition for periprosthetic joint infection: from the Workgroup of the Musculoskeletal Infection Society. Clin Orthop Relat Res 469:2992–2994
Trampuz A, Hanssen AD, Osmon DR, Mandrekar J, Steckelberg JM, Patel R (2004) Synovial fluid leukocyte count and differential for the diagnosis of prosthetic knee infection. Am J Med 117:556–562
Tornero E, Morata L, Martínez-Pastor JC, Bori G, Climent C, García-Velez DM, García-Ramiro S, Bosch J, Mensa J, Soriano A (2015) KLIC-score for predicting early failure in prosthetic joint infections treated with debridement, implant retention and antibiotics. Clin Microbiol Infect 21(786):e9–e17
Kim HS, Park JW, Moon SY, Lee YK, Ha YC, Koo KH (2020) Current and future burden of periprosthetic joint infection from national claim database. J Korean Med Sci 35:e410
Kunutsor SK, Beswick AD, Whitehouse MR, Wylde V, Blom AW (2018) Debridement, antibiotics and implant retention for periprosthetic joint infections: a systematic review and meta-analysis of treatment outcomes. J Infect 77:479–488
Chen W, Klemt C, Smith EJ, Tirumala V, Xiong L, Kwon YM (2021) Outcomes and risk factors associated with failures of debridement, antibiotics, and implant retention in patients with acute hematogenous periprosthetic joint infection. J Am Acad Orthop Surg. https://doi.org/10.5435/JAAOS-D-20-00939
Malahias MA, Gu A, Harris EC, Adriani M, Miller AO, Westrich GH, Sculco PK (2020) The role of long-term antibiotic suppression in the management of peri-prosthetic joint infections treated with debridement, antibiotics, and implant retention: a systematic review. J Arthroplasty 35:1154–1160
The authors thank Sohee Oh, PhD of the Medical Research Collaborating Center (MRCC) at Seoul Metropolitan Government-Seoul National University Boramae Medical Center for assistance with statistical analyses.
There was no external funding for this study.
Ethics approval and consent to participate
This study was approved by institutional review boards of Seoul National University Hospital (J-2103-041-1203), SMG-SNU Boramae Medical Center (B-2104-677-401), and Seoul National University Bundang Hospital (10-2021-29).
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All subjects in this study agreed to use their data for publication.
The authors declare that they have no competing interests.
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Chang, M.J., Ro, D.H., Kim, T.W. et al. Worse outcome of debridement, antibiotics, and implant retention in acute hematogenous infections than in postsurgical infections after total knee arthroplasty: a multicenter study. Knee Surg & Relat Res 34, 38 (2022). https://doi.org/10.1186/s43019-022-00165-z
- Total knee arthroplasty
- Periprosthetic joint infection
- Acute postsurgical infection
- Acute hematogenous infection