- Research article
- Open Access
- Published:
How much preoperative flexion contracture is a predictor for residual flexion contracture after total knee arthroplasty in hemophilic arthropathy and rheumatoid arthritis?
Knee Surgery & Related Research volume 34, Article number: 20 (2022)
Abstract
Background
Although total knee arthroplasty (TKA) in hemophilic arthropathy (HA) or rheumatoid arthritis (RA) can improve functional ability, the postoperative range of motion (ROM) and prosthesis durability are reduced compared with those in osteoarthritic patients.
Aim
We aimed to compare (1) the pre- and postoperative flexion contracture after TKA in HA and RA, (2) the threshold of preoperative flexion contracture as a predictor of residual contracture > 15° after TKA, and (3) the survival rate.
Methods
Data from a consecutive cohort comprising 48 TKAs in HA and 92 TKAs in RA were retrospectively reviewed. The degree of flexion contracture was analyzed. Through receiver operating characteristics analysis, we aimed to determine the cutoff value of preoperative flexion contracture that increases the risk of residual contracture > 15° after TKA and compare the cutoff value in HA and RA. The survival rate was evaluated based on life table analysis and the Kaplan–Meier method.
Results
The degree of preoperative flexion contracture was not significantly different. The degree of postoperative residual flexion contracture was 5.6° in the HA group and 1.4° in the RA group, respectively (p < 0.001). The cutoff value of preoperative flexion contracture for residual contracture of > 15° at last-follow up was 25.0° in the HA group and 32.5° in the RA group. The 5- and 12-year survival rates were 96% and 87% in the HA and 99% and 95% in the RA group, respectively (n.s.).
Conclusions
The postoperative residual flexion contracture was greater and the cutoff value of preoperative flexion contracture for residual contracture was smaller in the HA group than the RA group. Appropriate intra- and postoperative care to avoid postoperative residual contracture is required in HA patients.
Level of evidence
III.
Background
Most existing literature on the results of total knee arthroplasty (TKA) has focused on patients with degenerative osteoarthritis (OA) because it is the most common type of knee arthritis [1,2,3,4]. Contrary to OA, HA and RA have similar disease characteristics, including preceding synovial hypertrophy and subsequent cartilage destruction, periarticular soft tissue contracture, high incidence of flexion and valgus deformity of the knee, poor bone quality, involvement of multiple joints, and long duration of disease progression [5]. TKA in both HA and RA is technically demanding due to extensive arthrofibrosis and combined severe deformities [6, 7], with a high rate of complications [8, 9]. Although efforts are made to delay the timing of surgery, TKA is often performed earlier in relatively young HA or RA patients due to the long disease duration and functional disability.
Even slight loss of knee extension may have a significant negative impact on gait and functional ability. Flexion contracture increases energy consumption and places undue strain on the quadriceps [10, 11]. Although surgeons have attempted to avoid residual flexion contracture during TKA procedures, massive soft tissue release can increase the risk of postoperative instability, especially in RA with severe flexion contracture [12]. Hwang et al. [13] performed TKA in RA according to the rule of one-third correction of flexion contracture and conducted serial casting and physical therapy, obtaining full extension with two-thirds gradual correction of flexion contracture. Atilla et al. [14] found that the flexion contracture at final follow-up was related to the severity of the initial preoperative flexion contracture, with a threshold of 27.5° to avoid residual contracture > 15° after TKA in HA patients. To the best of the authors’ knowledge, no previous study has compared the threshold of preoperative flexion contracture as a predisposing factor of residual flexion contracture after TKA in HA and RA.
Most studies on TKA in HA and RA indicate that complications such as periprosthetic joint infection (PJI) and loosening are more frequent than in patients with degenerative osteoarthritis [3, 15,16,17,18]. Song et al. [15] reported a high incidence of PJI and periprosthetic fracture (3 and 4 of 131 knees, 2.3% and 3.1%) after TKA in HA. Lee et al. [19] reported high risk of complication and revision TKA in RA. Revision TKA was necessary in 19 (15.9%) knees at a mean of 12.2 (range 6–16) years postoperatively. To the best of the authors’ knowledge, no studies have compared the incidence of complications and survival rate after TKA in HA and RA.
This study aimed to compare (1) the pre- and postoperative flexion contracture after TKA in HA and RA, (2) the threshold of preoperative flexion contracture as a predictor of residual contracture > 15° after TKA, and (3) the incidence of complications and survival rate.
Patients and Methods
Patients
For HA, 52 TKAs were consecutively performed in 41 patients aged < 65 years from 2002 to 2018 at the tertiary medical center. Indications for TKA were end-stage HA of the knee with Arnold–Hilgartner stage IV and V [20], gait disturbance and functional impairment due to severe pain and limited range of motion (ROM), and unresponsive to conservative treatment. For RA, 100 consecutive TKAs (70 patients aged < 65 years) during the same operating period were included. Indication for TKA was RA with functional impairment of the knee unresponsive to conservative treatment.
Patients without minimal 2-year follow-up were excluded, and four TKAs (four patients) in HA and eight (seven patients) in RA were excluded. The study was approved by our institutional review board (KHMC 21-04-093).
Demographic data are presented in Table 1. There was no significant difference in terms of preoperative flexion contracture and follow-up periods between the HA and RA groups (Tables 1 and 2).
Operative technique
HA patients received coagulation factor replacement therapy according to our institutional protocol as per the World Hemophilia Foundation guidelines [6, 21]. The protocol was modified depending on patient’s factor levels, pharmacokinetic parameters such as recovery and half-life, and surgical wound status. Patients with high-titer inhibitors were treated with activated recombinant factor VIIa. Antithrombotic chemical prophylaxis was not used in HA patients but rather aspirin was used in RA patients.
The identical surgical technique of TKA with modified measured resection was applied in HA and RA patients [15]. General anesthesia is preferable due to the risk of spinal bleeding in HA patients [22]. A midline skin incision and medial parapatellar approach was used in all RA patients and most HA patients (Table 1). For proper exposure, a rectus snip was required in one knee, and V–Y quadricepsplasty was performed in three knees of the HA group (Table 1); these procedures were selectively performed only when there was a severe restriction on knee flexion because of concern about postoperative extension lag. Tibial tuberosity osteotomy was not applied in HA and RA patients due to poor quality of the periarticular bone [23]. Contemporary prostheses were implanted (Table 1). We preferred to additionally resect the distal femoral bone at 2–4 mm in severe flexion contractures > 20° rather than performing posterior capsulotomy. All components were implanted using bone cement mixed with 1 g of cephalosporin. Careful hemostasis was performed after deflating the tourniquet. Patellar resurfacing was performed in most knees, except in two and six knees with extremely small and thin patella in HA and RA patients, respectively (Table 1). The Hemovac drain was removed 2 days postoperatively, and active knee joint exercise was initiated. After 3 days, patients were mobilized with crutches until 1 month postoperatively. In patients who underwent rectus snip or V–Y quadricepsplasty, the ROM was restricted with a brace in extension, and the active extension and straight leg-raising exercise were withheld for 10 days to avoid postoperative extension lag. HA patients were discharged and referred to the Korea Hemophilia Foundation (KHF) for rehabilitation at a median of 9 days postoperatively. RA patients were discharged to home or convalescent center at a median of 7 days postoperatively. HA and RA patients had sequential follow-up at 6 weeks, 3 months, 6 months, and 1 year after surgery and were followed up annually thereafter.
Clinical evaluation
The Knee Society knee and function scores [24] and Western Ontario and McMaster Universities Arthritis Index (WOMAC) [25] were used to evaluate pain and function both preoperatively and at last follow-up (Table 2). Flexion contracture, maximum flexion, and ROM were measured using a long-arm goniometer, with the patient in supine position.
Radiographic evaluation
Serial pre- and postoperative anteroposterior and lateral radiographs and orthoroentgenograms were used to assess limb alignment, component position, and patellar height. Measurements were made on these images using a picture archiving and communication system (PACS) (Infinitt Healthcare Co. Ltd., Seoul, Korea). The patellar height was measured pre- and postoperatively using the Insall–Salvati ratio (ISR) and Blackburne–Peel ratio (BPR). Patella baja was defined as a truly low-lying patella due to shortening of the patellar tendon, which is associated with ISR of < 0.8 and BPR of < 0.54. Pseudo-patella baja was defined as a relatively low-lying patella to joint line, which is associated with normal ISR and BPR of < 0.54 [26].
Complications
Any complications and need for additional surgery following primary TKA were reviewed according to the Knee Society classification system [27]. Prosthetic loosening was defined as occurring in knees with progressive radiolucent line > 2 mm wide on any radiograph, visible fracture of the cement around the components, or changes in component position, including subsidence [28].
Statistical analysis
Preoperative and last follow-up values were compared using the paired t-test. Continuous variables between HA and RA groups were compared using Student’s t-test. Discrete variables were compared using the chi squared test and Fisher’s exact test. Preoperative and last follow-up values of flexion contracture and maximum flexion were compared using correlation analysis in both HA and RA groups. Through receiver operating characteristics (ROC) analysis, we aimed to determine the minimum amount of preoperative flexion contracture that increases the risk of residual contracture > 15° after TKA [14] and compare the cutoff value in HA and RA. Residual flexion contracture > 15° was thought to be clinically significant because it affects the patients’ walking ability [29].
The survival rate was evaluated based on life table analysis and the Kaplan–Meier method. The follow-up interval unit was 1 year, and annual success was defined as instances in which the implant remained in place throughout the time period.
All statistical analyses were performed using SPSS software (version 20.0; SPSS, Inc., Chicago, IL). In all analyses, p < 0.05 was considered statistically significant.
Results
Clinical evaluation
Clinical score and ROM are presented in Table 2. The degree of preoperative flexion contracture was not significantly different. The degree of flexion contracture at last follow-up was greater in the HA group (5.6° versus 1.4°, p < 0.001). The decreasing amount of flexion contracture did not differ between the groups. Although the maximum flexion and ROM at last follow-up were smaller in the HA group than in the RA group, the increasing amount did not differ between the groups. The maximum flexion angle at last follow-up positively correlated with the preoperative maximum flexion angle in the HA and RA groups (Fig. 1). There was a wide range of pre- and postoperative maximum flexion angle on the scattergram, and the maximum flexion angle was decreased after TKA in 17 knees (35.4%) of the HA group (Fig. 1A). The RA groups had minimal 95° of postoperative maximum flexion angle in every knee (Fig. 1B). Flexion contracture at last follow-up was positively correlated with preoperative flexion contracture in both the HA and RA groups (Fig. 2). There was a wide range of preoperative flexion contracture on the scattergram, which was decreased to < 15° in most patients after TKAs (Fig. 2A, B). However, five knees (10.4%) in the HA group and four (4.3%) in the RA group had residual flexion contracture of > 15° (p = 0.274). When evaluating the cutoff point of preoperative flexion contracture for postoperative residual contracture > 15° at last follow-up on ROC analysis, the cutoff value was 25.0° in the HA group and 32.5° in the RA group (Fig. 3). Significant postoperative extension lag was not observed, especially in cases with intraoperative rectus snip or V–Y quadricepsplasty.
Radiographic evaluation
The pre- and postoperative mechanical axis (MA) results are presented in Table 3. Half (24/48 knees) of the patients in the HA group and 21.7% (20/92 knees) of those in the RA group had preoperative valgus alignment. The proportion of aligned postoperative MA within ±3° was 39 knees (81.3%) in the HA group and 84 knees (85.7%) in the RA group (p = 0.084). The position of components did not differ between the groups (Table 3). Fourteen knees (29.2%) in the HA group and four knees (14.3%) in the RA group had patella baja preoperatively, which remained postoperatively (Table 4; Fig. 4). Postoperative pseudo-patella baja newly occurred in five knees (10.4%) in the HA group and eight knees (8.7%) in the RA group (Table 4).
Improvement of flexion contracture after TKA in patients with severe flexion contracture of > 30°. A Correction of flexion contracture in hemophilic arthropathy. The preoperative flexion contracture was decreased, but sustained after TKA in a patient with hemophilic arthropathy. B Correction of flexion contracture in rheumatoid arthritis. The preoperative flexion contracture was fully corrected after TKA in a patient with rheumatoid arthritis
Complications and additional surgeries
In the HA group, there were 19 bleeding and hemarthrosis cases (Table 5). Twelve knees were treated with increased amounts of coagulation factor concentrate, and seven were treated with incision and drainage of the hematoma. In the RA group, one intraoperative grade 2 avulsion injury of the medial collateral ligament required change of postoperative rehabilitation protocol and bracing (Table 5). Six knees in the HA group and one in the RA group had stiffness and required manipulation under anesthesia (p = 0.007). There was one periprosthetic fracture of the distal femur in the HA group, which was treated with open reduction and internal fixation. Three patients with PJI were treated with stage 2 revision TKA in the HA group (p = 0.039). There were one case of femoral component loosening in the HA group and two cases of loosening in the RA group, which required revision TKAs.
Survivorship analysis
In the HA group, three knees (6.3%) underwent revision TKA at 3 months, 1.7 years, and 9.1 years after primary TKA due to PJI. One knee underwent revision TKA at 10.6 years after primary TKA due to loosening. In the RA group, two knees (2.2%) underwent revision TKA at 6 months and 11.2 years after primary TKA due to loosening. The 5- and 12-year survival rates were 96% and 87% in the HA group and 99% and 95% in the RA group, respectively (Fig. 5).
Discussion
The most important finding of the present study is that the residual flexion contracture after TKA in end-stage HA was larger than that in the RA group, although there was no difference in the preoperative flexion contracture. In a previous study with long-term follow-up after TKA in 112 RA patients (176 knees) [19], the average flexion contracture was 27.0° preoperatively and 1.8° at last follow-up. Contrary to HA, complete correction of the preoperative flexion contracture is not obligate during TKA for RA patients because it can be gradually corrected and extension exercise is effective after TKA [13]. However, aggressive application of surgical strategies and rehabilitation protocol seems necessary for RA patients with severe preoperative flexion contracture from the data of the present study because four knees (4.3%) in the RA group had residual flexion contracture > 15°.
The second most important finding is that the cutoff value of preoperative flexion contracture to avoid a residual contracture > 15° at last follow-up was 7.5° smaller in the HA group than that in the RA group (25.0° in the HA group versus 32.5° in the RA group) (Fig. 3). These data reveal that the amount of preoperative flexion contracture should be more actively considered in HA than in RA when selecting the timing of TKA. Kubes et al. [30] reported that hemophilic patients should be operated before the preoperative flexion contracture reaches 22° to obtain a contracture < 15° postoperatively or before the preoperative contracture reaches 12° to obtain a contracture < 5°. In HA, repeated intraarticular bleeding occurs with subsequent intraarticular deposition of hemosiderin and iron, which leads to upregulation of proinflammatory cytokines and, consequently, synovial hypertrophy and articular destruction [31]. Therefore, it is thought that attentively passive and assisted active exercise of knee flexion–extension is necessary to decrease the risk of periarticular bleeding with proper factor replacement during rehabilitation after TKA in HA. Contrary to in HA, RA patients experience less intracapsular fibrotic changes and extracapsular muscle contractures and seem to have gradual correction of flexion contracture after TKA.
Another important finding of this study is that postoperative hemarthrosis was one of the common complications in HA, with prevalence rates of 25% and 8.9% in the present study and the previous metaanalysis, respectively [32]. Wong et al. [21] recommended coagulation factor replacement at a higher level for a longer period than that in the current World Hemophilia Foundation guidelines. We believe that the prevalence of bleeding might have been decreased if we had used a high coagulation factor replacement regime, maintaining a 100% level of coagulation factor throughout the first 3 weeks following TKA [33]. Most studies about TKA in HA and RA indicate that complications such as PJI and loosening are more frequent than in patients with degenerative osteoarthritis [3, 15,16,17,18]. With a special emphasis on late PJI, Rodriguez-Merchan et al. [34] reported an infection rate of 6.8% (early infection 1.1%, late infection 5.7%) in TKA in HA. The cause of the high incidence of PJI after TKA in HA is still unknown [7], but it may be due to poor skin condition caused by coagulation factor administration, immunosuppression, concomitant human immunodeficiency virus (HIV) or hepatitis C virus (HCV) infection, or bacteremia from contamination during repeated intravenous self-administration of coagulation factor concentrate [1, 33]. In the HA groups of the present study, three knees (6.3%) underwent revision TKA at 3 months, 1.7 years, and 9.1 years after primary TKA due to PJI. The low incidence of late PJI in our cohort may have been because the patients were well supervised by KHF with education on meticulous sterility during self-infusion, and regular medical checkups in addition to the low proportion of immunosuppressed patients positive for HIV (Table 1).
Solimeno et al. [35] reported an aseptic loosening rate requiring revision TKA of 6% in HA patients with a median time to implant removal of 7 years. In the present study with mean follow-up of 8.8 years, there was one loosening at 10.6 years after TKA for HA patients. Young age, poor bone quality, microhemorrhages, and reactive destructive reactions at the bone–cement interface are potential causes of the high incidence of aseptic loosening [7]. HA patients are generally younger than those with osteoarthritis and are expected to have higher levels of physical activity after TKA, so they may have a higher risk of loosening. However, Zingg et al. [36] noted that HA patients generally have few demands in daily living and have adapted to their musculoskeletal problems since childhood. Interestingly, there were two incidences of loosening at 6 months and 11.2 years after TKA in RA patients in the present study with mean follow-up of 8.0 years. HA and RA patients had similar incidence of loosening after TKA and period of revision TKA. This finding shows that the period of loosening should be considered in selecting the timing of TKA for HA and RA.
The present study has several limitations. The principal limitation is its retrospective nature with small sample size. However, it would be difficult to conduct a prospective study or a matched pair analysis when considering the rare incidence of TKA in HA and RA patients. Second, differences existed in demographics such as age, sex, body mass index, and duration of disease between the HA and RA groups. But considering the etiology and pathophysiological characteristics of HA and RA, these differences were inevitable. Third, serial change of flexion contracture after TKA was not investigated in our study. This would be an interesting issue because flexion contracture could get worse with time in the HA group (due to recurrent hemarthrosis and subsequent fibrosis), but not in the RA group. Further study on this issue will be required. Last, TKA procedures were performed by experienced surgeons (S.J.S. and D.K.B.) in a tertiary medical center with a good hemophilia care system. This means that caution must be taken when seeking to extrapolate our findings to countries with different medical situations and general hospitals.
Despite some limitations, data from the present study can be used to inform HA and RA patients about the threshold of preoperative flexion contracture for the risk of residual flexion contracture, complications, and survival rate after TKA.
Conclusion
The postoperative residual flexion contracture was greater and the cutoff value of preoperative flexion contracture for residual contracture was smaller in the HA group than the RA group. Appropriate intra- and postoperative care to avoid postoperative residual contracture is required in HA patients.
Availability of data and materials
Not applicable.
Abbreviations
- TKA:
-
Total knee arthroplasty
- HA:
-
Hemophilic arthropathy
- RA:
-
Rheumatoid arthritis
- ROM:
-
Range of motion
- OA:
-
Osteoarthritis
- PJI:
-
Periprosthetic joint infection
- KHF:
-
Korea Hemophilia Foundation
- WOMAC:
-
Western Ontario and McMaster Universities Arthritis Index
- PACS:
-
Picture archiving and communication system
- ISR:
-
Insall–Salvati ratio
- BPR:
-
Blackburne–Peel ratio
- ROC:
-
Receiver operating characteristics
- MA:
-
Mechanical axis
- HIV:
-
Human immunodeficiency virus
- HCV:
-
Hepatitis C virus
References
Burnham RR Jr, Bialek SE, Wozniak A, Brown NM (2020) Does contralateral knee range of motion predict postoperative knee range of motion after total knee arthroplasty? Knee Surg Relat Res 32(1):26
Chang MJ, Kang SB, Chang CB et al (2020) Posterior condylar offset changes and its effect on clinical outcomes after posterior-substituting, fixed-bearing total knee arthroplasty: anterior versus posterior referencing. Knee Surg Relat Res 32(1):10
Choi YJ, Seo DK, Lee KW, Ra HJ, Kang HW, Kim JK (2020) Results of total knee arthroplasty for painless, stiff knees. Knee Surg Relat Res 32(1):61
Goto K, Katsuragawa Y, Miyamoto Y (2020) Outcomes and component-positioning in total knee arthroplasty may be comparable between supervised trained surgeons and their supervisor. Knee Surg Relat Res 32(1):3
Hoots WK (2006) Pathogenesis of hemophilic arthropathy. Seminars in hematology. Elsevier, Amsterdam, pp S18–S22
Bae DK, Yoon KH, Kim HS, Song SJ (2005) Total knee arthroplasty in hemophilic arthropathy of the knee. J Arthroplasty 20(5):664–668
Kang DG, Khurana S, Baek JH, Park YS, Lee SH, Kim KI (2014) Efficacy and safety using autotransfusion system with postoperative shed blood following total knee arthroplasty in haemophilia. Haemophilia 20(1):129–132
Ernstbrunner L, Hingsammer A, Catanzaro S et al (2016) Long-term results of total knee arthroplasty in haemophilic patients: an 18-year follow-up. Knee Surg Sports Traumatol Arthrosc 25(11):3431–3438
Strauss AC, Schmolders J, Friedrich MJ et al (2015) Outcome after total knee arthroplasty in haemophilic patients with stiff knees. Haemophilia 21(4):e300–e305
Cheuy VA, Foran JRH, Paxton RJ, Bade MJ, Zeni JA, Stevens-Lapsley JE (2017) Arthrofibrosis associated with total knee arthroplasty. J Arthroplasty 32(8):2604–2611
Magit D, Wolff A, Sutton K, Medvecky MJ (2007) Arthrofibrosis of the knee. J Am Acad Orthop Surg 15(11):682–694
Yan D, Yang J, Pei F (2013) Total knee arthroplasty treatment of rheumatoid arthritis with severe versus moderate flexion contracture. J Orthop Surg Res 8:41
Hwang YS, Moon KP, Kim KT, Kim JW, Park WS (2016) Total knee arthroplasty for severe flexion contracture in rheumatoid arthritis knees. Knee Surg Relat Res 28(4):325–329
Atilla B, Caglar O, Pekmezci M, Buyukasik Y, Tokgozoglu AM, Alpaslan M (2012) Pre-operative flexion contracture determines the functional outcome of haemophilic arthropathy treated with total knee arthroplasty. Haemophilia 18(3):358–363
Song SJ, Bae JK, Park CH, Yoo MC, Bae DK, Kim KI (2018) Mid-term outcomes and complications of total knee arthroplasty in haemophilic arthropathy: a review of consecutive 131 knees between 2006 and 2015 in a single institute. Haemophilia 24(2):299–306
Rosas S, Buller LT, Plate J, Higuera C, Barsoum WK, Emory C (2019) Total knee arthroplasty among medicare beneficiaries with hemophilia A and B is associated with increased complications and higher costs. J Knee Surg 34(04):372–377
Wang SH, Chung CH, Chen YC, Cooper AM, Chien WC, Pan RY (2019) Does hemophilia increase risk of adverse outcomes following total hip and knee arthroplasty? A propensity score-matched analysis of a nationwide, population-based study. J Arthroplasty 34(10):2329-2336.e1
Lee DK, Kim HJ, Cho IY, Lee DH (2017) Infection and revision rates following primary total knee arthroplasty in patients with rheumatoid arthritis versus osteoarthritis: a meta-analysis. Knee Surg Sports Traumatol Arthrosc 25(12):3800–3807
Lee JK, Kee YM, Chung HK, Choi CH (2015) Long-term results of cruciate-retaining total knee replacement in patients with rheumatoid arthritis: a minimum 15-year review. Can J Surg 58(3):193–197
Ng WH, Chu WC, Shing MK et al (2005) Role of imaging in management of hemophilic patients. AJR Am J Roentgenol 184(5):1619–1623
Wong JM, Mann HA, Goddard NJ (2012) Perioperative clotting factor replacement and infection in total knee arthroplasty. Haemophilia 18(4):607–612
Rodriguez-Merchan EC (2013) Special features of total knee replacement in hemophilia. Expert Rev Hematol 6(6):637–642
Mortazavi SJ, Bagheri N, Farhoud A, Hadi Kalantar S, Ghadimi E (2020) Total knee arthroplasty in patients with hemophilia: what do we know? Arch Bone Jt Surg 8(4):470–478
Insall JN, Dorr LD, Scott RD, Scott WN (1989) Rationale of the knee society clinical rating system. Clin Orthop Relat Res 248:13–14
Giesinger JM, Hamilton DF, Jost B, Behrend H, Giesinger K (2015) WOMAC, EQ-5D and knee society score thresholds for treatment success after total knee arthroplasty. J Arthroplasty 30(12):2154–2158
Bugelli G, Ascione F, Cazzella N et al (2018) Pseudo-patella baja: a minor yet frequent complication of total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 26(6):1831–1837
Healy WL, Della Valle CJ, Iorio R et al (2013) Complications of total knee arthroplasty: standardized list and definitions of the knee society. Clin Orthop Relat Res 471(1):215–220
Bae DK, Song SJ, Heo DB, Lee SH, Song WJ (2013) Long-term survival rate of implants and modes of failure after revision total knee arthroplasty by a single surgeon. J Arthroplasty 28(7):1130–1134
Kagaya H, Ito S, Iwami T, Obinata G, Shimada Y (2003) A computer simulation of human walking in persons with joint contractures. Tohoku J Exp Med 200(1):31–37
Kubes R, Salaj P, Hromadka R et al (2018) Range of motion after total knee arthroplasty in hemophilic arthropathy. BMC Musculoskelet Disord 19(1):162
Santos Silva M, Rodrigues-Pinto R, Rodrigues C, Morais S, Costa ECJ (2019) Long-term results of total knee arthroplasty in hemophilic arthropathy. J Orthop Surg 27(1):2309499019834337
Moore MF, Tobase P, Allen DD (2016) Meta-analysis: outcomes of total knee arthroplasty in the haemophilia population. Haemophilia 22(4):e275–e285
Rahme M, Ehlinger M, Faradji A et al (2012) Total knee arthroplasty in severe haemophilic patients under continuous infusion of clotting factors. Knee Surg Sports Traumatol Arthrosc 20(9):1781–1786
Rodriguez-Merchan EC (2015) Total knee arthroplasty in hemophilic arthropathy. Am J Orthop 44(12):E503–E507
Solimeno LP, Mancuso ME, Pasta G, Santagostino E, Perfetto S, Mannucci PM (2009) Factors influencing the long-term outcome of primary total knee replacement in haemophiliacs: a review of 116 procedures at a single institution. Br J Haematol 145(2):227–234
Zingg PO, Fucentese SF, Lutz W, Brand B, Mamisch N, Koch PP (2012) Haemophilic knee arthropathy: long-term outcome after total knee replacement. Knee Surg Sports Traumatol Arthrosc. 20(12):2465–2470
Acknowledgements
Not applicable.
Funding
Not applicable.
Author information
Authors and Affiliations
Contributions
The following authors made substantial contributions to the following: (1) conception and design of the study (S.J.S., H.W.L.), provision of study materials or patients (S.J.S., D.K.B.), data acquisition (H.W.L., C.H.P.), analysis and interpretation of data (H.W.L., C.H.P.); (2) drafting the article (S.J.S., D.K.B., C.H.P., H.W.L.); (3) final approval of the version to be submitted (S.J.S.). All authors read and approved the final manuscript.
Corresponding author
Ethics declarations
Ethics approval and consent to participate
Patients included in this study agreed that their personal information and radiographic data could be used for future research. This study was approved by our institutional review board (KHMC 21-04-093).
Consent for publication
Not applicable.
Competing interests
The authors declare that they have no competing interests.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
About this article
Cite this article
Lee, H.W., Park, C.H., Bae, D.K. et al. How much preoperative flexion contracture is a predictor for residual flexion contracture after total knee arthroplasty in hemophilic arthropathy and rheumatoid arthritis?. Knee Surg & Relat Res 34, 20 (2022). https://doi.org/10.1186/s43019-022-00146-2
Received:
Accepted:
Published:
DOI: https://doi.org/10.1186/s43019-022-00146-2
Keywords
- Knee
- Hemophilia
- Rheumatoid arthritis
- Arthroplasty
- Flexion contracture
- Complications