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Table 1 Details of clinical studies

From: Calcium phosphate injection of symptomatic bone marrow lesions of the knee: what is the current clinical evidence?

Author and yearNumber of patientsAge at presentation/ mean (±SD)/median (range)Duration of nonoperative treatment (pre-procedure)Mechanical axis evaluated preoperatively (Y/N)Bone substitute material usedPostoperative regimen Weight- bearingDuration of follow up (months)
Mean (±SD)/median (range)
Outcome measuresComplications (number)
Conway et al. [20] 2019154NRNAccuFill®Toe-touch24VASIncreased pain
Bonadio et al. [12] 2017567.7(±9.67)3YGraftys HBS®Full6 (±NR)KOOS
VAS
Graft extravasation (1)
Byrd et al. [21] 201713357 (38–84)NRNAccuFill®NR32.1 (24–43)VASNR
Cohen et al. [11] 20166655.9 (35–76)2YAccuFill®As tolerated + crutches24 (NR)VAS
IKDC
Persistent drainage (1)
Deep vein thrombosis (1)
Chatterjee et al. [17] 20152253.5 (38–70)3YAccuFill®Partial (2/52)12 (6–24)KOOS
T-L
NR
Nevalainen et al. [7] 2015242
58
8
NR
N
N
AccuFill®
AccuFill®
NR
NR
6
14
NR
NR
NR
NR
Farr et al. [13] 20135955.6 (35–76)6YAccuFill®As tolerated + crutches14.7 (±NR)VAS
IKDC
SF12
Extravasation (N/R)
Significant pain treated with nerve block (NR)
Davis et al. [22] 20155055 (36–82)NRNRNRNR14.6 (12.9–25.1)VASNR
  1. SD standard deviation, NR not reported, Y yes, N no, VAS visual analog scale, KOOS Knee injury and Osteoarthritis Outcome Score, IKDC International Knee Documentation Committee, T-L Tegner Lysholm Knee Scoring Scale, SF-12 Short Form Survey Score