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Table 4 Complication comparison after TKA between PD and control patients

From: The effect of Parkinson’s disease on total knee arthroplasty: a systematic review and meta-analysis

Journal

Year

Author

PD

Control

Complication

Acta Orthop. Belg

2013

Craig

Deep vein thrombosis, superficial infection, urinary retention, urinary tract infection, quadriceps avulsion, posterior tibial dislocation

Deep infection, urinary retention, patella subluxation, aseptic loosening

 

JBJS

2014

Jämsen

PD had no statistical association with the 1-year infection rate at longer follow-up (~5 years), patients with PD had higher mortality [hazard ratio 1.94 (1.68–2.25)]

 

No difference between PD cases and controls in mortality at 90 days, 180 days, or 1 year

J Arthroplasty

2017

Rodon

Aseptic loosening: three (4.2%)

Peri-prosthetic joint infection: nine (12.7%)

Arthrofibrosis: three (4.2%)

Patella clunk syndrome: none (0%)

Aseptic loosening: one (0.8%) p = 0.0909

Peri-prosthetic joint infection: none (0%), p < 0.0001

Arthrofibrosis: three (2.3%) p = 0.4328

Patella clunk syndrome: eight (6.1%) p = 0.0348

 

J Arthroplasty

2018

Wong

Deep vein thrombosis: three; superficial wound infection: one

Deep vein thrombosis: one

Bowel pseudo-obstruction: one

No difference

J Orthop Surg Res

2019

Xiao

  

Gastrointestinal disorder: two; delirium: one; upper respiratory infection: one

KSSTA

2019

Newman

Medical complication odds ratio

Delirium: 3.57 (2.80–4.54)

Altered mental status: 2.46 (1.48–4.09)

Pneumonia: 1.35 (1.01–1.81)

Urinary tract infection: 1.25 (1.08–1.44)

Transfusion of blood: 1.46 (1.34–1.57)

Cognitive symptoms, stroke, acute myocardial infarction, pulmonary, gastrointestinal, acute renal failure, pulmonary embolism, deep venous thrombosis: n.s

Surgical complication odds ratio

Hematoma: 1.01 (0.75–7.35)

Wound infection: 1.39 (0.53–3.65)

Wound dehiscence: 1.00 (0.32–3.10)

Injury–peripheral nerve: 1.50 (0–28-8.19)

Irrigation and debridement: 1.42 (0.64–3.14)

  

Knee

2019

Kleiner

In-hospital complication rate: 8.3%

All complication odds ratio: 1.036 (0.949–1.130)

In-hospital mortality: 0.16%

In-hospital complication rate: 8.0% (p = 0.4297)

In-hospital mortality: 0.15%

Complications were more likely in older patients and patients with increased CCI

No difference in complication rate or mortality between PD patients and matched non-PD patients

AOTS

2020

Veronica

  

Confusion and flexion contracture were the most frequent perioperative complications

JKS

2020

Marchand

Medical complication odds ratio

Transfusion rate: odds ratio 6.79 (4.74–9.74)

Acute post-hemorrhagic anemia: 4.75 (3.85–5.86)

Cerebrovascular accident: 3.48 (2.04–5.94)

Thrombocytopenia: 3.37 (1.72–6.62)

Urinary tract infection: 3.29 (2.73–3.97)

Acute kidney failure: 2.74 (2.00–3.76)

Pneumonia: 2.70 (1.72–4.24)

Other postoperative infections: 1.67 (1.09–2.57)

total medical complications: 3.50 (3.15–3.89)

Implant-related complication odds ratio

Other mechanical complications: 2.61 (2.13–3.21)

Peri-prosthetic fracture: 2.26 (1.70–3.01)

Dislocation: 2.22 (1.83–2.69)

Broken prosthetic joint implants: 1.79 (1.27–2.53)

Peri-prosthetic joint infection: 1.19 (1.04–1.35)

Mechanical loosening: 1.33 (1.05–1.69)

Revision total knee arthroplasties: 1.55 (0.83–2.89)

Total implant-related complications: 1.64 (1.51–1.79)

  

J Arthroplasty

2020

Goh

Medical complications

Arrhythmia: one; hypotension: three; acute kidney injury: three; urinary tract infection: one; pneumonia 1, delirium 3

Surgical complications: deep infection: one

Wound complication: surgical site infection: one; dehiscence one

Medical complication

Acute kidney injury: one; acute pancreatitis: one; delirium: two

Wound complication: surgical site infection: one; hematoma: one

All complication comparison: p = 0.030

J of AAOS

2022

Cheppalli

Odds ratio

Blood loss anemia: 1.501 (p < 0.001)

Peri-prosthetic dislocation: 3.813 (p < 0.001)

Peri-prosthetic mechanical complication: 1.936 (p = 0.024)

Mortality: NA(p = 0.294)

Peri-prosthetic infection: 1.190 (p = 0.287)

  
  1. CCI: Charlson Comorbidity index; PD: Parkinson’s disease