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Table 3 Reported outcomes – visual analogue scale (VAS) following intraarticular injection of autologous conditioned serum/autologous protein solution (ACS/APS)

From: Autologous cell-free serum preparations in the management of knee osteoarthritis: what is the current clinical evidence?

Author and yearStudy patientsAge at presentation
Mean (± SD)/median (range)
Follow-up (months)
Mean (± SD)/median (range)
Outcome measureBaselinePost procedure
Score
Mean (± SD)/median (range)
Time point(s)
(weeks/months)
Score
Mean (± SD)/median (range)
Kon et al. 2018 [22]4657 (41–68)12 (± NR)VAS5.5 (± NR)12 monthsNRa
Tassara et al. 2018 [24]2568 (34–87)6 (± NR)VAS80 (70–100)1 month20 (0–60)
6 months20 (0–60)
Barreto et al. 2017 [31, 32]10061.2 (± 1.2)12 (± NR)VAS5.8 (± 0.6)1 week4.2 (± NR)
2 weeks3.3 (± NR)
3 months3.1 (± NR)
6 months3.2 (± NR)
12 months2.3 (± NR)
Hang et al. 201792NR12 (± NR)VAS6.07 (± NR)12 months2.52 (± NR)
Shirokova et al. 2017 [34]12359.9 (± 8.8)3 (± NR)VASNRb3 monthsNRb
Rutgers et al. 2015 [36]2050 (34–70)12 (± NR)VAS52.20 (± 22.90)12 months50.05 (± 23.76)
Baltzer et al. 2009 [38]37653.8 (± 12.2)25 (± NR)VAS69.6 (± 13.10)6 months29.5 (± 22.58)
  1. NR
  2. avisual analogue scale (VAS) at 12 months reported to be 49% better but numeric score not provided
  3. bVAS at 3 months reported to be 47% better but VAS value not provided