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Table 3 Reported outcomes – visual analogue scale (VAS) following intraarticular injection of autologous conditioned serum/autologous protein solution (ACS/APS)

From: Autologous cell-free serum preparations in the management of knee osteoarthritis: what is the current clinical evidence?

Author and year Study patients Age at presentation
Mean (± SD)/median (range)
Follow-up (months)
Mean (± SD)/median (range)
Outcome measure Baseline Post procedure
Score
Mean (± SD)/median (range)
Time point(s)
(weeks/months)
Score
Mean (± SD)/median (range)
Kon et al. 2018 [22] 46 57 (41–68) 12 (± NR) VAS 5.5 (± NR) 12 months NRa
Tassara et al. 2018 [24] 25 68 (34–87) 6 (± NR) VAS 80 (70–100) 1 month 20 (0–60)
6 months 20 (0–60)
Barreto et al. 2017 [31, 32] 100 61.2 (± 1.2) 12 (± NR) VAS 5.8 (± 0.6) 1 week 4.2 (± NR)
2 weeks 3.3 (± NR)
3 months 3.1 (± NR)
6 months 3.2 (± NR)
12 months 2.3 (± NR)
Hang et al. 2017 92 NR 12 (± NR) VAS 6.07 (± NR) 12 months 2.52 (± NR)
Shirokova et al. 2017 [34] 123 59.9 (± 8.8) 3 (± NR) VAS NRb 3 months NRb
Rutgers et al. 2015 [36] 20 50 (34–70) 12 (± NR) VAS 52.20 (± 22.90) 12 months 50.05 (± 23.76)
Baltzer et al. 2009 [38] 376 53.8 (± 12.2) 25 (± NR) VAS 69.6 (± 13.10) 6 months 29.5 (± 22.58)
  1. NR
  2. avisual analogue scale (VAS) at 12 months reported to be 49% better but numeric score not provided
  3. bVAS at 3 months reported to be 47% better but VAS value not provided