Table 2 Medical comorbidities by chronic opioid outcome N(%)
From: Risk factors and trajectories of opioid use following total knee replacement
Condition | Chronic | Non-chronic | Total | p-Value |
|---|---|---|---|---|
Congestive heart failure | 203 (17.7%) | 87 (16.8%) | 290 (17.4%) | 0.73 |
Valvular disease | 175 (15.2%) | 81 (15.7%) | 256 (15.4%) | 0.83 |
Pulmonary circulation disease | 90 (7.8%) | 27 (5.2%) | 117 (7.0%) | 0.062 |
Peripheral vascular disease | 180 (15.7%) | 68 (13.2%) | 248 (14.9%) | 0.21 |
Hypertension without complications | 1029 (89.6%) | 461 (89.2%) | 1490 (89.4%) | 0.8 |
Hypertension with complications | 164 (14.3%) | 57 (11.0%) | 221 (13.3%) | 0.073 |
Paralysis | 38 (3.3%) | 20 (3.9%) | 58 (3.5%) | 0.56 |
Other neurological disorders | 233 (20.3%) | 101 (19.5%) | 334 (20.0%) | 0.74 |
Chronic pulmonary disease | 625 (54.4%) | 218 (42.2%) | 843 (50.6%) | < 0.0001 |
Diabetes without chronic complications | 378 (32.9%) | 191 (36.9%) | 569 (34.2%) | 0.12 |
Diabetes with chronic complications | 288 (25.1%) | 133 (25.7%) | 421 (25.3%) | 0.81 |
Hypothyroidism | 223 (19.4%) | 104 (20.1%) | 327 (19.6%) | 0.74 |
Renal failure | 191 (16.6%) | 73 (14.1%) | 264 (15.8%) | 0.22 |
Liver disease | 153 (13.3%) | 36 (7.0%) | 189 (11.3%) | 0.0001 |
Peptic ulcer disease | 35 (3.0%) | 12 (2.3%) | 47 (2.8%) | 0.53 |
Acquired immune deficiency syndrome | 11 (1.0%) | 8 (1.5%) | 19 (1.1%) | 0.32 |
Rheumatoid arthritis | 262 (22.8%) | 88 (17.0%) | 350 (21.0%) | 0.008 |
Coagulopathy | 60 (5.2%) | 18 (3.5%) | 78 (4.7%) | 0.13 |
Obesity | 727 (63.3%) | 310 (60.0%) | 1037 (62.2%) | 0.21 |
Weight loss | 91 (7.9%) | 37 (7.2%) | 128 (7.7%) | 0.62 |
Fluid and electrolyte disorders | 399 (34.7%) | 156 (30.2%) | 555 (33.3%) | 0.073 |
Chronic blood loss anemia | 49 (4.3%) | 24 (4.6%) | 73 (4.4%) | 0.7 |
Deficiency anemias | 434 (37.8%) | 195 (37.7%) | 629 (37.8%) | 1.0 |
Alcohol abuse | 81 (7.0%) | 30 (5.8%) | 111 (6.7%) | 0.4 |
Substance use disorder | 195 (17.0%) | 45 (8.7%) | 240 (14.4%) | < 0.0001 |
Psychoses | 244 (21.2%) | 100 (19.3%) | 344 (20.6%) | 0.4 |
Osteoporosis | 98 (8.5%) | 45 (8.7%) | 143 (8.6%) | 0.92 |
Depression | 507 (44.1%) | 187 (36.2%) | 694 (41.7%) | 0.003 |
Opioid use disorder | 100 (8.7%) | 22 (4.3%) | 122 (7.3%) | 0.001 |
Sleep apnea | 366 (31.9%) | 163 (31.5%) | 529 (31.8%) | 0.91 |
Number of chronic conditions, mean (std) | 6.7 (3.2) | 6.0 (2.9) | 6.5 (3.1) | < 0.0001 |