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Table 4 Results for mortality

From: Is there an optimal age for total knee arthroplasty?: A systematic review

Author

Journal

Year

Number

Age (years)

Result

Difference

 Murphy [14]

Bone Joint J

2018

2838

< 80,

≥ 80

Mortality hazard ratio in ≥ 80-years group is 3.40 (2.54–4.54, P < 0.001)

 Skinner [37]

Ann R Coll Surg Eng

2016

67

70–79,

90–99

Mortality rates were higher in the nonagenarian group but these were in keeping with the life expectancy projections identified by the Office for National Statistics

 Shah [20]

J knee Surg

2016

33,066

< 65,

≥ 65

Young cohort had lower rate of mortality (0.03 vs. 0.18%, P < 0.001)

 Jauregui [39]

J Arthroplast

2015

35,342

< 90,

≥ 90

Serious postoperative adverse events that were significantly higher in nonagenarians compared to controls included death (0.9% vs. 0.2%; P = 0.024)

 Maempel [40]

Acta Orthop

2015

3144

< 75,

75–80,

> 80

Odds ratios for mortality at 1 year, adjusted for ASA, were 2.2 (1.0–4.5) for age 75–80, and 3.0 (1.3–6.8) for age > 80, relative to age < 75 years

 Belmont [42]

J Bone Joint Surg Am

2014

15,321

 

Patient age (OR = 1.12; 95% CI, 1.06 to 1.17) was independent predictor of mortality

 D’Apuzzo [43]

J Arthroplast

2014

5,492,805

< 90,

≥ 90

In-hospital mortality was significantly higher in the older cohort compared to the younger group (2.9% versus 0.2%; P < 0.001)

 Easterlin [46]

Clin Orthop Rel Res

2013

8950

40–64,

65–69,

70–74,

75–79,

80–84,

85–89

Age was associated with increased risk of mortality starting at age 85 years; mortality in patients 85 years and older was 17 times higher than in those younger than 65 years (OR: 70–74 (1.21), 75–79 (2.85), 80–84 (2.57), 85–89 (17.65)

 Kennedy [48]

Clin Orthop Rel Res

2013

≥ 80: 438

< 80: 2754

< 80,

≥ 80

Octogenarians had a higher (P < 0.001) mortality rate in Kaplan-Meier survival analysis

 Jämsen [51]

Acta Orthop

2012

1998

75–79,

80–84,

≥ 85

Adjusted hazard ratio for age 75–79 years is 1, for 80–84 years it is 1.71 [1.31–2.23], for 85 years or over it is 3.34 (2.39–4.65)

 Singh [52]

J Arthroplast

2012

12,484

 

Older age was associated with higher 90-day all-cause mortality. OR for age (per 5-year increase) is 1.6 (1.3–1.9) in univariate analysis and 1.6 (1.2–1.7) in multivariable-adjusted analysis

 Kreder [59]

J Arthroplast

2005

15,029

65–79,

> 80

Patients > 80 years of age are 3.4 times more likely to die

No difference

 Kuo [44]

J Orthop Surg Res

2014

1024

< 80,

≥ 80

There was no 90-day mortality in either group

 Robertsson [58]

Bone Joint J

2007

57,979

< 54,

55–59,

60–64,

65–69,

70–74,

75–79,

80–84,

> 85

Patients younger than 55 years had a statistically significant increase in total mortality (standardized mortality ratio: 1.85 [1.53–2.22]) while patients older than 65 years had a statistically significant decrease

  1. OR odds ratio