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Table 3 Effectiveness of iron supplementation

From: Effectiveness of iron supplementation in the perioperative management of total knee arthroplasty: a systematic review

Author Year Journal Transfusion indication Transfusion rate_iron
(N, %)
Transfusion rate_control
(N, %)
Hb_iron (g/dL) Hb_control (g/dL)
Park et al. [26] 2019 J Clin Med Hb < 8 g/dL throughout the perioperative period
Hemodynamic instability
2 (6.9%) 4 (12.8%) Pre-OP (12.5 ± 1.3)
POD 1D (10.3 ± 1.4)
POD 5D (9.5 ± 1.2)
POD 30D (12.8 ± 1.3)
Pre-OP (13.4 ± 1.1)
POD 1D (10.7 ± 1.3)
POD 5D (9.9 ± 1.6)
POD 30D (12.6 ± 1.1)
Heschl et al. [30] 2018 Eur J Anaesthesiol Hb < 7 g/dL for healthy patients
Hb < 8 g/dL for cardiopulmonary restriction patients
40 (12)% 79 (24%) Pre-OP (12.9 ± 1.7)
POD discharge (10.7 ± 1.3)
Pre-OP (12.2 ± 1.1)
POD discharge (10.6 ± 1.1)
Muñoz et al. [31] 2014 Blood transfusion Hb < 8 g/dL throughout the perioperative periodHemodynamic instability `21 (11.5%) 48 (26.4%) Pre-OP (13.8 ± 1.2)
POD 3D (10.4 ± 1.6)
POD 7D (10.6 ± 1.3)
Pre-OP (13.6 ± 1.2)
POD 3D (9.2 ± 1.5)
POD 7D (9.2 ± 2.2)
Muñoz et al. [32] 2012 Br J Anaesth Hb < 8 g/dL for healthy patients
Hb < 9 g/dL for active cardiac disease
Low-dose: 20 (62%)
High -dose: 29 (46%)
16 (84%) Low-dose
Pre-OP (11.8 ± 1.2)
POD 1D (8.7 ± 0.8)
POD 7D (9.6 ± 0.7)
High-dose
Pre-OP (12.4 ± 1.3)
POD 1D (9.1 ± 0.6)
POD 7D (9.8 ± 0.9)
Pre-OP (12.5 ± 1.5)
POD 1D (8.7 ± 1.0)
POD 7D (10.1 ± 0.7)
Na et al. [25] 2011 Transfusion Hb: 6 ~ 7: 1 pack
5 ~ 6: 2 pack
11 (20.4%) 29 (53.7%) Pre-OP (12.1 ± 1.3)
Significantly higher Hb level than control group at POD 1D, 2D, 3D, 2 W, 6 W
Pre-OP (12.1 ± 1.2) Significantly lower Hb level than iron supplementation group at POD 1D, 2D, 3D, 2 W, 6 W
Gonzalez-Porras et al. [29] 2009 Transfus Med Hb < 7 g/dL for healthy patients
Hb < 8 g/dL for poor tolerance of anemia Hb < 9 g/dL for cardiac or respiratory failure
Oral: 29 (20%)
IV: 10 (20.4%)
96 (31.5%) Oral
Pre-OP (14.3 ± 0.8)
POD discharge (10.7 ± 0.1)
IV
Pre-OP (13.3 ± 0.2)
POD discharge (10.3 ± 0.8)
Pre-OP (13.8 ± 1.4)
POD discharge (10.7 ± 0.8)
Mundy et al. [24] 2005 JBJS   9 (18%) 5 (10.2) Men
Pre-OP (15.1 ± 1.2)
POD 1D (11.0 ± 1.8)
POD 5D (10.8 ± 1.6)
POD 3 weeks (13.0 ± 1.2)
POD 6 weeks (13.8 ± 1.1)
Women
Pre-OP (13.3 ± 0.9)
POD 1D (9.4 ± 1.3)
POD 5D (10.3 ± 1.6)
POD 3 weeks (11.9 ± 1.1)
POD 6 weeks (12.5 ± 0.9)
Men
Pre-OP (14.9 ± 0.9)
POD 1D (11.4 ± 1.2)
POD 5D (10.6 ± 0.9)
POD 3 weeks (12.8 ± 0.8)
POD 6 weeks (13.3 ± 1.4)
Women
Pre-OP (13.4 ± 1.3)
POD 1D (9.5 ± 1.4)
POD 5D (9.8 ± 1.1)
POD 3 weeks (11.7 ± 1.4)
POD 6 weeks (12.0 ± 1.4)
Sutton et al. [27] 2004 JBJS     Pre-OP (12.7)
Post-OP (10.4)
At review (12.4)
Pre-OP (12.9)
Post-OP (10.5)
At review (12.1)
Weatherall et al. [28] 2004 ANZ J Surg     Pre-OP (14.0 ± 1.3)
POD 10 weeks (13.3 ± 1.3)
Pre-OP (13.7 ± 1.1)
POD 10 weeks (12.8 ± 1.1)
  1. D day, W week, At review: mean 47 ~ 48 day, OP operation, POD post-operation day, Hb hemoglobin