Skip to main content

Table 2 Evaluation of the effectiveness of iron supplementation by comparing with control group

From: Effectiveness of iron supplementation in the perioperative management of total knee arthroplasty: a systematic review

Author Year Journal Study design Inclusion criteria N
(iron)
N
(control)
OP Treatment timing Additional treatment PBM protocol Iron IV or Oral Dose
Park et al. [26] 2019 J Clin Med Randomized controlled trial Hb ≥ 10 g/dLSerum-ferritin < 300 mg/dL (male) or 200 mg/dL (female) 29 29 TKA or
THA
Intra-OP    FCM IV 1000 mg
Heschl et al. [30] 2018 Eur J Anaesthesiol Retrospective cohort study Hb < 13 g/dL (men), <  12 g/dL (women) 331 331 TKA or
THA
Pre-OP +EPO   FCM IV 2*1 g
Biboulet et al. [22] 2018 Anesthesiology Randomized controlled trial Hb: 10 ~ 13 g/dL Oral 50
IV 50
  TKA or
THA
Pre-OP +EPO   IV: FCM
Oral: Ferrous sulfate
Oral or IV IV (1000 mg)
Oral (160 mg*2/day for 3 weeks)
Bisbe et al. [23] 2014 Br J Anaesth Randomized controlled trial Hb: 8.5 ~ 12.0 g/dL Oral 62
IV 59
  TKA Post-OP   Oral tranexamic acid, tourniquet IV: FCM
Oral: Ferrous sulfate
Oral or IV IV: single IV injection by Ganzoni formula
Oral: 100 mg/day for POD 7 ~ POD 30
Muñoz et al. [31] 2014 Blood transfusion Retrospective cohort study Hb ≥ 10 g/dL 182 182 TKA or
THA
Post-OP   Tourniquet Iron sucroseFCM IV 200 mg (3 consecutive post-operative days) or600 mg FCM on POD 1
Muñoz et al. [32] 2012 Br J Anaesth Retrospective cohort study Hb < 10 g/dL on POD 1 Low dose 32High- dose 63 19 TKA or
THA
Post-OP    Iron sucroseFCM IV 100 mg* 3 days 200 mg* 3 days or 600 mg FCM
Na et al. [25] 2011 Transfusion Randomized controlled trial Hb ≥ 10 g/dL andserum ferritin < 100 ng/L, orserum ferritin 100 ~ 300 ng/L and transferrin saturation < 20% 54 54 TKA (bilateral) Intra-OP + Post-OP +EPO   Iron sucrose IV 200 mg (Post-OP Hb 7 ~ 8 g/dL, injection 2 times more)
Gonzalez-Porras et al. [29] 2009 Transfus Med Prospective cohort study Oral: Hb ≥ 13 g/dL and ferritin < 250 μg/LIV: Hb ≥ 13 g/dL and ferritin < 50 μg/L 80 49 TKA or
THA
Pre-OP    Oral: ferrous sulfateIV: iron sucrose Oral or IV Oral: 315 mg/day IV: 200 mg/week (minimum 2 weeks)
Mundy et al. [24] 2005 JBJS Randomized controlled trial Hb ≥ 13 g/dL (men), ≥ 11.5 g/dL (women)Serum-ferritin < 300 mg/dL (male) or 200 mg/dL (female) 50 49 TKA or
THA
Post-OP    Ferrous sulfate Oral 200 mg three times daily (POD 2 ~ POD 3 weeks)
Sutton et al. [27] 2004 JBJS Randomized controlled trial Hb ≥ 12 g/dL (men), ≥ 11 g/dL (women) 35 37 TKA or
THA
Post-OP    Ferrous sulfate Oral 200 mg three times daily (~ 6 weeks after discharge)
Weatherall et al. [28] 2004 ANZ J Surg Randomized controlled trial Hb ≥ 12 g/dL 33 34 TKA or
THA
Post-OP    Ferrous gluconate Oral 325 mg (~ 10 weeks after surgery)
  1. TKA total knee arthroplasty, THA total hip arthroplasty, Hb hemoglobin, EPO erythropoietin, OP operation, FCM ferric carboxymaltose, PBM perioperative blood management, IV intravenous