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Table 2 Methods used to calculate minimal clinically important difference

From: Minimal clinically important difference of commonly used patient-reported outcome measures in total knee arthroplasty: review of terminologies, methods and proposed values

Citation

Test

Method

Anchor question

Transitional scale

Quintana et al., 2006 [16]

WOMAC and SF-36

Mean change

Not specified

5-point scale

Escobar et al., 2007 [14]

WOMAC and SF-36

Mean change

Not specified

5-point scale

Chesworth et al., 2008 [13]

WOMAC*

ROC

“Compared to when they went on the wait list for surgery, they were better, worse or the same”

15-point scale

Escobar et al., 2013 [17]

WOMAC*

Mean change

ROC

“Compared to before surgery, how would you rate pain (functional limitation) in the same knee?”

“Was surgery worthwhile?”

“What is your global level of satisfaction with surgical management?”

5-point scale

Clement et al., 2014 [18]

OKS and SF-12 PCS

Linear regression analysis

“How well did the surgery relieve pain in your affected joint?”

“How well did the surgery increase your ability to perform regular activities?”

5-point scale

Escobar et al., 2014 [15]

WOMAC*

Mean change

Not specified

5-point scale

Maratt et al., 2015 [12]

WOMAC*

ROC

“How much did your knee surgery improve the quality of your life?

6-point scale

Beard et al., 2015 [28]

OKS

Mean difference

Mean change and ROC

“Overall, how are your problems now, compared to before your operation?”

5-point scale

Lee et al., 2017 [21]

KSS

Linear regression analysis

How would you rate the overall results of the surgery for your knee condition?”

6-point scale

Ingelsrud et al., 2018 [29]

OKS

Mean change

Logistic regression and ROC

“How are your knee problems now compared to prior to operation?”

7-point scale

Lizaur-Utrilla et al., 2019 [23]

KSS

Mean difference

ROC and 0.5 SD

“Compared to before surgery, how would you rate the pain in your knee and the ability to perform regular activities now?

5-point scale

Clement et al., 2019 [25]

SF-12

Mean difference

ROC

“How much did the knee replacement surgery improve the quality of your life?”

5-point scale

Kiran et al., 2014 [19]

OKS

0.5 SD

Distribution-based method

Keurentjes et al. 2014 [26]

SF-36

0.8 SD

Distribution-based method

Kiran, et al., 2015 [27]

OKS

0.5 SD

Distribution-based method

Bin Abd Razak et al., 2016 [20]

OKS and SF-36 PCS

0.5 SD

Distribution-based method

Berliner, et al., 2017 [22]

SF-12 PCS

0.5 SD

Distribution-based method

Blevins et al., 2019 [24]

SF-12

0.5 SD

Distribution-based method

  1. MCID minimal clinically important difference, TKA total knee arthroplasty, PROM patient-reported outcome measures, WOMAC Western Ontario And McMaster University Arthritis Index, WOMAC* Western Ontario and McMaster University Arthritis Index reversed scoring system, OKS Oxford Knee Score, KSS Knee Society Score, SF-36 36-item Short Form survey, PCS physical component summary, SF-12 12-item Short Form Survey, ROC receiver operator characteristics, 0.5 SD half of a standard deviation, , 0.8 SD four fifths of a standard deviation