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Table 4 Reported outcomes – Western Ontario and McMaster Universities osteoarthritis instrument (WOMAC) following intraarticular injection of autologous conditioned serum/autologous protein solution (ACS/APS)

From: Autologous cell-free serum preparations in the management of knee osteoarthritis: what is the current clinical evidence?

Author and year Study patients Age at presentation
Mean (± SD)/median (range)
Follow-up (months)
Mean (± SD)/median (range)
Outcome measure Baseline Post procedure
Score
Mean (± SD)/median (range)
Time point(s) (weeks/months) Score
Mean (± SD)/median (range)
Kon et al. 2018 [22] 46 57 (41–68) 12 (± NR) WOMAC 51.2 (± NR) 12 months NRa
Hang et al. 2017 92 NR 12 (± NR) WOMAC Function – 70.3 (± NR) 12 months Function – 27.2 (± NR)
Mobility – 8.6 (± NR) 12 months Mobility – 3.1 (± NR)
Pain – 20.9 (± NR) 12 months Pain – 9.0 (± NR)
Shirokova et al. 2017 [34] 123 59.9 (± 8.8) 3 (± NR) WOMAC NRb 3 months NRb
Hix et al. 2017 [20] 10 58.8 (± 9.5) 12 (± NR) WOMAC Pain – 12.0 (± 1.2) 12 months Pain – 3.3 (± 2.9)
van Drumpt et al. 2016 [21] 10 57.5 (± 9.5) 18 (± 1) WOMAC 55 (± NR) 12 months 20 (± NR)
Garcia-Escudero et al. 2015 [35] 118 59 (34–81) 24 (± NR) WOMAC Global – 81.6 (± NR) 12 months Global – 35.2 (± NR)
Function – 60.4 (± NR) 12 months Function – 29.4 (± NR)
Stiffness – 3.36 (± NR) 12 months Stiffness – 3.3 (± NR)
Pain – 17.9 (± NR) 12 months Pain – 2.5 (± NR)
Motaal et al. 2014 [37] 30 54.21 (± 5.95) 3 (± NR) WOMAC Total – 45.63 (± 9.99) 1 week Total – 26.23 (± 11.50)
1 month Total – 8.0 (± 7.28)
2 months Total – 7.52 (± 6.91)
3 months Total – 8.27 (± 5.45)
Baltzer et al. 2009 [38] 376 53.8 (± 12.2) 25 (± NR) WOMAC Global – 5.24 (± 2.32) 7 weeks Global – 2.80 (± 2.30)
13 weeks Global – 2.42 (± 2.06)
26 weeks Global – 2.42 (± 2.19)
Pain – 5.18 (± 2.39) 7 weeks Pain – 2.71 (± 2.37)
13 weeks Pain – 2.33 (± 2.14)
26 weeks Pain – 2.42 (± 2.25)
Stiffness – 5.59 (± 2.7) 7 weeks Stiffness – 3.07 (± 2.49)
13 weeks Stiffness – 2.80 (± 2.33)
26 weeks Stiffness – 2.78 (± 2.45)
Function – 5.21 (± 2.41) 7 weeks Function – 2.80 (± 2.34)
13 weeks Function – 2.40 (± 2.08)
26 weeks Function – 2.37 (± 2.21)
Yang et al. 2008 [39] 153 54 (± 11) 12 (± NR) WOMAC 54.49 (± 17.6) 3 months 63.37 (± 20.6)
6 months 62.90 (± 23.7)
9 months 61.78 (± 23.4)
12 months 65.02 (± 24.1)
  1. NR
  2. aWOMAC at 12 months reported to be 49% better but numeric score not provided
  3. bWOMAC at 3 months reported to be 28.7% better but numeric score not provided