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Table 4 Reported outcomes – Western Ontario and McMaster Universities osteoarthritis instrument (WOMAC) following intraarticular injection of autologous conditioned serum/autologous protein solution (ACS/APS)

From: Autologous cell-free serum preparations in the management of knee osteoarthritis: what is the current clinical evidence?

Author and yearStudy patientsAge at presentation
Mean (± SD)/median (range)
Follow-up (months)
Mean (± SD)/median (range)
Outcome measureBaselinePost procedure
Score
Mean (± SD)/median (range)
Time point(s) (weeks/months)Score
Mean (± SD)/median (range)
Kon et al. 2018 [22]4657 (41–68)12 (± NR)WOMAC51.2 (± NR)12 monthsNRa
Hang et al. 201792NR12 (± NR)WOMACFunction – 70.3 (± NR)12 monthsFunction – 27.2 (± NR)
Mobility – 8.6 (± NR)12 monthsMobility – 3.1 (± NR)
Pain – 20.9 (± NR)12 monthsPain – 9.0 (± NR)
Shirokova et al. 2017 [34]12359.9 (± 8.8)3 (± NR)WOMACNRb3 monthsNRb
Hix et al. 2017 [20]1058.8 (± 9.5)12 (± NR)WOMACPain – 12.0 (± 1.2)12 monthsPain – 3.3 (± 2.9)
van Drumpt et al. 2016 [21]1057.5 (± 9.5)18 (± 1)WOMAC55 (± NR)12 months20 (± NR)
Garcia-Escudero et al. 2015 [35]11859 (34–81)24 (± NR)WOMACGlobal – 81.6 (± NR)12 monthsGlobal – 35.2 (± NR)
Function – 60.4 (± NR)12 monthsFunction – 29.4 (± NR)
Stiffness – 3.36 (± NR)12 monthsStiffness – 3.3 (± NR)
Pain – 17.9 (± NR)12 monthsPain – 2.5 (± NR)
Motaal et al. 2014 [37]3054.21 (± 5.95)3 (± NR)WOMACTotal – 45.63 (± 9.99)1 weekTotal – 26.23 (± 11.50)
1 monthTotal – 8.0 (± 7.28)
2 monthsTotal – 7.52 (± 6.91)
3 monthsTotal – 8.27 (± 5.45)
Baltzer et al. 2009 [38]37653.8 (± 12.2)25 (± NR)WOMACGlobal – 5.24 (± 2.32)7 weeksGlobal – 2.80 (± 2.30)
13 weeksGlobal – 2.42 (± 2.06)
26 weeksGlobal – 2.42 (± 2.19)
Pain – 5.18 (± 2.39)7 weeksPain – 2.71 (± 2.37)
13 weeksPain – 2.33 (± 2.14)
26 weeksPain – 2.42 (± 2.25)
Stiffness – 5.59 (± 2.7)7 weeksStiffness – 3.07 (± 2.49)
13 weeksStiffness – 2.80 (± 2.33)
26 weeksStiffness – 2.78 (± 2.45)
Function – 5.21 (± 2.41)7 weeksFunction – 2.80 (± 2.34)
13 weeksFunction – 2.40 (± 2.08)
26 weeksFunction – 2.37 (± 2.21)
Yang et al. 2008 [39]15354 (± 11)12 (± NR)WOMAC54.49 (± 17.6)3 months63.37 (± 20.6)
6 months62.90 (± 23.7)
9 months61.78 (± 23.4)
12 months65.02 (± 24.1)
  1. NR
  2. aWOMAC at 12 months reported to be 49% better but numeric score not provided
  3. bWOMAC at 3 months reported to be 28.7% better but numeric score not provided