Table 4 Reported outcomes – Western Ontario and McMaster Universities osteoarthritis instrument (WOMAC) following intraarticular injection of autologous conditioned serum/autologous protein solution (ACS/APS)
Author and year | Study patients | Age at presentation Mean (± SD)/median (range) | Follow-up (months) Mean (± SD)/median (range) | Outcome measure | Baseline | Post procedure | |
|---|---|---|---|---|---|---|---|
Score Mean (± SD)/median (range) | Time point(s) (weeks/months) | Score Mean (± SD)/median (range) | |||||
Kon et al. 2018 [22] | 46 | 57 (41–68) | 12 (± NR) | WOMAC | 51.2 (± NR) | 12 months | NRa |
Hang et al. 2017 | 92 | NR | 12 (± NR) | WOMAC | Function – 70.3 (± NR) | 12 months | Function – 27.2 (± NR) |
Mobility – 8.6 (± NR) | 12 months | Mobility – 3.1 (± NR) | |||||
Pain – 20.9 (± NR) | 12 months | Pain – 9.0 (± NR) | |||||
Shirokova et al. 2017 [34] | 123 | 59.9 (± 8.8) | 3 (± NR) | WOMAC | NRb | 3 months | NRb |
Hix et al. 2017 [20] | 10 | 58.8 (± 9.5) | 12 (± NR) | WOMAC | Pain – 12.0 (± 1.2) | 12 months | Pain – 3.3 (± 2.9) |
van Drumpt et al. 2016 [21] | 10 | 57.5 (± 9.5) | 18 (± 1) | WOMAC | 55 (± NR) | 12 months | 20 (± NR) |
Garcia-Escudero et al. 2015 [35] | 118 | 59 (34–81) | 24 (± NR) | WOMAC | Global – 81.6 (± NR) | 12 months | Global – 35.2 (± NR) |
Function – 60.4 (± NR) | 12 months | Function – 29.4 (± NR) | |||||
Stiffness – 3.36 (± NR) | 12 months | Stiffness – 3.3 (± NR) | |||||
Pain – 17.9 (± NR) | 12 months | Pain – 2.5 (± NR) | |||||
Motaal et al. 2014 [37] | 30 | 54.21 (± 5.95) | 3 (± NR) | WOMAC | Total – 45.63 (± 9.99) | 1 week | Total – 26.23 (± 11.50) |
1 month | Total – 8.0 (± 7.28) | ||||||
2 months | Total – 7.52 (± 6.91) | ||||||
3 months | Total – 8.27 (± 5.45) | ||||||
Baltzer et al. 2009 [38] | 376 | 53.8 (± 12.2) | 25 (± NR) | WOMAC | Global – 5.24 (± 2.32) | 7 weeks | Global – 2.80 (± 2.30) |
13 weeks | Global – 2.42 (± 2.06) | ||||||
26 weeks | Global – 2.42 (± 2.19) | ||||||
Pain – 5.18 (± 2.39) | 7 weeks | Pain – 2.71 (± 2.37) | |||||
13 weeks | Pain – 2.33 (± 2.14) | ||||||
26 weeks | Pain – 2.42 (± 2.25) | ||||||
Stiffness – 5.59 (± 2.7) | 7 weeks | Stiffness – 3.07 (± 2.49) | |||||
13 weeks | Stiffness – 2.80 (± 2.33) | ||||||
26 weeks | Stiffness – 2.78 (± 2.45) | ||||||
Function – 5.21 (± 2.41) | 7 weeks | Function – 2.80 (± 2.34) | |||||
13 weeks | Function – 2.40 (± 2.08) | ||||||
26 weeks | Function – 2.37 (± 2.21) | ||||||
Yang et al. 2008 [39] | 153 | 54 (± 11) | 12 (± NR) | WOMAC | 54.49 (± 17.6) | 3 months | 63.37 (± 20.6) |
6 months | 62.90 (± 23.7) | ||||||
9 months | 61.78 (± 23.4) | ||||||
12 months | 65.02 (± 24.1) | ||||||