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Table 2 List of relevant studies from literature

From: Autologous cell-free serum preparations in the management of knee osteoarthritis: what is the current clinical evidence?

Author and yearStudy patientsAge at presentation
Mean (± SD)/median (range)
BMI
Mean (± SD)/median (range)
OA severity (K-L grade/ACR criteria)Intraarticular injection and numberFollow-up (months)
Mean (± SD)/median (range)
Outcome measuresAdverse events (AE)/complicationsLevel of evidence
Kon et al. 2018 [22]4657 (41–68)NRK-L 2–3APS
1
12 (± NR)WOMAC
VAS
KOOS
SF-36
CGI-S/PGI-S
AE – 6
Arthralgia
2
Tassara et al. 2018 [24]2568 (34–87)NRNRACS
4
6 (± NR)VAS
ROM
None3
Zarringam et al. 2018 [23]12663 (NR)NRK-L 1–3ACS
6
90 (± 47)K-MNR3
Barreto et al. 2017 [31, 32]10061.2 (± 1.2)33.8 (± 1.4)ACRACS
6
12 (± NR)VAS
XSMFA-D
PGIC
NR3
Hang et al. 2017 [33]92NRNRNRACS
4
12 (± NR)VAS
WOMAC
NR3
Shirokova et al. 2017 [34]12359.9 (± 8.8)NRACRACS
6
3 (± NR)VAS
WOMAC
NR3
Hix et al. 2017 [20]1058.8 (± 9.5)29.0 (± 3.9)NRAPS
1
12 (± NR)WOMAC
KOOS
NRS
AE – 4
Arthralgia
Discomfort
3
van Drumpt et al. 2016 [21]1057.5 (± 9.5)26.6 (± 3.1)K-L 1–4APS
1
18 (± 1)WOMACAE – 6
Arthralgia
Joint stiffness
Injection site pain
3
Garcia-Escudero et al. 2015 [35]11859 (34–81)29.6 (± NR)K-L 1–4ACS
4
24 (± NR)WOMAC
NRS
None3
Rutgers et al. 2015 [36]2050 (34–70)NRK-L 1–3ACS
6
12 (± NR)VAS
KOOS
KSCRS
NR3
Motaal et al. 2014 [37]3054.21 (± 5.95)NRK-L 1–3ACS
3
3 (± NR)WOMACNR3
Baltzer et al. 2009 [38]37653.8 (± 12.2)NRK-L 2–3ACS
6
25 (± NR)WOMAC
SF-8
VAS
AE – 31
Joint swelling
Transient pain
2
Yang et al. 2008 [39]15354 (± 11)27 (± 5)K-L 1–3ACS
6
12 (± NR)WOMAC
KSCRS
Knee pain – 44
Irritation – 70
Swelling – 10
Septic arthritis – 1
2
  1. AE adverse events, BMI body mass index, ROM range of movement, SD standard deviation, NR not reported, APS autologous protein solution, ACS autologous conditioned serum, K-L Kellgren-Lawrence, ACR American College of Rheumatology criteria, VAS visual analogue scale, KOOS Knee injury and Osteoarthritis Outcome Score, WOMAC Western Ontario and McMaster Universities osteoarthritis instrument, OA osteoarthritis, SF-8 Short-Form 8 health-related quality of life, K-M Kaplan-Meier method, CGI-S Clinical Global Impression of Severity, PGI-S Patient Global Impression of Severity, XSMFA-D Extra Short Musculoskeletal Functional Assessment, KSCRS Knee Society clinical rating scale, NR