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Table 2 List of relevant studies from literature

From: Autologous cell-free serum preparations in the management of knee osteoarthritis: what is the current clinical evidence?

Author and year Study patients Age at presentation
Mean (± SD)/median (range)
BMI
Mean (± SD)/median (range)
OA severity (K-L grade/ACR criteria) Intraarticular injection and number Follow-up (months)
Mean (± SD)/median (range)
Outcome measures Adverse events (AE)/complications Level of evidence
Kon et al. 2018 [22] 46 57 (41–68) NR K-L 2–3 APS
1
12 (± NR) WOMAC
VAS
KOOS
SF-36
CGI-S/PGI-S
AE – 6
Arthralgia
2
Tassara et al. 2018 [24] 25 68 (34–87) NR NR ACS
4
6 (± NR) VAS
ROM
None 3
Zarringam et al. 2018 [23] 126 63 (NR) NR K-L 1–3 ACS
6
90 (± 47) K-M NR 3
Barreto et al. 2017 [31, 32] 100 61.2 (± 1.2) 33.8 (± 1.4) ACR ACS
6
12 (± NR) VAS
XSMFA-D
PGIC
NR 3
Hang et al. 2017 [33] 92 NR NR NR ACS
4
12 (± NR) VAS
WOMAC
NR 3
Shirokova et al. 2017 [34] 123 59.9 (± 8.8) NR ACR ACS
6
3 (± NR) VAS
WOMAC
NR 3
Hix et al. 2017 [20] 10 58.8 (± 9.5) 29.0 (± 3.9) NR APS
1
12 (± NR) WOMAC
KOOS
NRS
AE – 4
Arthralgia
Discomfort
3
van Drumpt et al. 2016 [21] 10 57.5 (± 9.5) 26.6 (± 3.1) K-L 1–4 APS
1
18 (± 1) WOMAC AE – 6
Arthralgia
Joint stiffness
Injection site pain
3
Garcia-Escudero et al. 2015 [35] 118 59 (34–81) 29.6 (± NR) K-L 1–4 ACS
4
24 (± NR) WOMAC
NRS
None 3
Rutgers et al. 2015 [36] 20 50 (34–70) NR K-L 1–3 ACS
6
12 (± NR) VAS
KOOS
KSCRS
NR 3
Motaal et al. 2014 [37] 30 54.21 (± 5.95) NR K-L 1–3 ACS
3
3 (± NR) WOMAC NR 3
Baltzer et al. 2009 [38] 376 53.8 (± 12.2) NR K-L 2–3 ACS
6
25 (± NR) WOMAC
SF-8
VAS
AE – 31
Joint swelling
Transient pain
2
Yang et al. 2008 [39] 153 54 (± 11) 27 (± 5) K-L 1–3 ACS
6
12 (± NR) WOMAC
KSCRS
Knee pain – 44
Irritation – 70
Swelling – 10
Septic arthritis – 1
2
  1. AE adverse events, BMI body mass index, ROM range of movement, SD standard deviation, NR not reported, APS autologous protein solution, ACS autologous conditioned serum, K-L Kellgren-Lawrence, ACR American College of Rheumatology criteria, VAS visual analogue scale, KOOS Knee injury and Osteoarthritis Outcome Score, WOMAC Western Ontario and McMaster Universities osteoarthritis instrument, OA osteoarthritis, SF-8 Short-Form 8 health-related quality of life, K-M Kaplan-Meier method, CGI-S Clinical Global Impression of Severity, PGI-S Patient Global Impression of Severity, XSMFA-D Extra Short Musculoskeletal Functional Assessment, KSCRS Knee Society clinical rating scale, NR