Calcium phosphate injection of symptomatic bone marrow lesions of the knee: what is the current clinical evidence?

Table 3 Reported clinical outcomes of calcium phosphate injection including Subchondroplasty®

Author and year	Number of patients	Age at presentation /mean (±SD)/ median (range)	Duration of follow up (months) Mean (±SD)/ median (range)	Outcome measure	Pre-procedure		Post-procedure
Author and year	Number of patients	Age at presentation /mean (±SD)/ median (range)	Duration of follow up (months) Mean (±SD)/ median (range)	Outcome measure	Time point(s) (weeks/months)	Score Mean (±SD)	Time point(s) (weeks/months)	Score Mean (±SD)
Chatterjee et al. [17] 2015	22^a 5/22 1/22	53.5 (38–70)	12 (6–24)	KOOS	NR NR NR	39.28 (±26.52) 42.56 (±18.62) 61.30 (±NA)	6 months^a 12 months^a 24 months^a	79.68 (±22.69) 86.78 (±10.71) 62.50 (±NA)
Cohen et al. [11] 2016	66^a 35/66 26/66	55.9 (35–76)	24 (NR)	IKDC	NR	30.5 (±NR)	6 months 24 months	47.7 (±NR) 48.3 (±NR)
Farr et al [13] 2013	59	55.6 (35–76)	14.7 (±NR)	IKDC	NR	30.6 (±NR)	6 months	53.0 (±NR)
Chatterjee et al. [17] 2015	22^a 5/22 1/22	53.5 (38–70)	12 (6–24)	T-L	NR NR NR	52.00 (±15.47) 49.20 (±6.53) 44.00 (±NA)	6 months^a 12 months^a 24 months^a	86.50 (±12.72) 90.20 (±7.16) 47.00 (±NA)
Farr et al. [13] 2013	59	55.6 (35–76)	14.7 (±NR)	SF12	NR	29.8 (±NR)	6	36.7 (±NR)

SD standard deviation, NR not reported, NA not applicable, VAS visual analog scale, KOOS Knee injury and Osteoarthritis Outcome Score, IKDC International Knee Documentation Committee, T-L Tegner Lysholm Knee Scoring score, SF-12 Short Form Survey score)
^a Limited patients at follow up: 6 months, n = 6, 12 months, n = 5, 24 months, n = 1

ISSN: 2234-2451