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Table 3 Reported clinical outcomes of calcium phosphate injection including Subchondroplasty®

From: Calcium phosphate injection of symptomatic bone marrow lesions of the knee: what is the current clinical evidence?

Author and yearNumber of patientsAge at presentation /mean (±SD)/ median (range)Duration of follow up (months)
Mean (±SD)/ median (range)
Outcome measurePre-procedurePost-procedure
Time point(s) (weeks/months)Score
Mean (±SD)
Time point(s) (weeks/months)Score
Mean (±SD)
Chatterjee et al. [17] 201522a
5/22
1/22
53.5 (38–70)12 (6–24)KOOSNR
NR
NR
39.28 (±26.52)
42.56 (±18.62)
61.30 (±NA)
6 monthsa
12 monthsa
24 monthsa
79.68 (±22.69)
86.78 (±10.71)
62.50 (±NA)
Cohen et al. [11] 201666a
35/66
26/66
55.9 (35–76)24 (NR)IKDCNR30.5 (±NR)6 months
24 months
47.7 (±NR)
48.3 (±NR)
Farr et al [13] 20135955.6 (35–76)14.7 (±NR)IKDCNR30.6 (±NR)6 months53.0 (±NR)
Chatterjee et al. [17] 201522a
5/22
1/22
53.5 (38–70)12 (6–24)T-LNR
NR
NR
52.00 (±15.47)
49.20 (±6.53)
44.00 (±NA)
6 monthsa
12 monthsa
24 monthsa
86.50 (±12.72)
90.20 (±7.16)
47.00 (±NA)
Farr et al. [13] 20135955.6 (35–76)14.7 (±NR)SF12NR29.8 (±NR)636.7 (±NR)
  1. SD standard deviation, NR not reported, NA not applicable, VAS visual analog scale, KOOS Knee injury and Osteoarthritis Outcome Score, IKDC International Knee Documentation Committee, T-L Tegner Lysholm Knee Scoring score, SF-12 Short Form Survey score)
  2. a Limited patients at follow up: 6 months, n = 6, 12 months, n = 5, 24 months, n = 1