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Table 2 Reported clinical outcomes of calcium phosphate injection including Subchondroplasty®

From: Calcium phosphate injection of symptomatic bone marrow lesions of the knee: what is the current clinical evidence?

Author and year

Number of patients

Age at presentation /mean (±SD)/ median (range)

Duration of follow up (months)

Mean (±SD)/ median (range)

Outcome measure

Pre-procedure

Post-procedure

Time point(s) (weeks/months)

Score

Mean (±SD)

Time point(s) (weeks/months)

Score

Mean (±SD)

Bonadio et al. [12] 2017

5

67.7(±9.67)

6 (±NR)

VAS

1 week

7.8 (±NR)

1 week

3 weeks

6 weeks

12 weeks

24 weeks

2.8 (±NR)

3.0 (±NR)

2.8 (±NR)

1.8 (±NR)

0.6 (±NR)

Byrd et al. [21] 2017

133

57 (38–84)

32.1 (24–43)

VAS

NR

8.3 (±NR)

NR

3.4 (±NR)

Cohen et al. [11] 2016

66a

55.9 (35–76)

24 (NR)

VAS

NR

7.6 (±NR)

6 months

24 months

3.3 (±NR)

3.2 (±NR)

Davis et al. [22] 2015

50

55 (36–82)

14.6 (12.9–25.1)

VAS

NR

8.3 (±NR)

NR

3.6 (±NR)

Farr et al. [13] 2013

59

55.6 (35–76)

14.7 (±NR)

VAS

NR

7.5 (±NR)

6 months

3.1 (±NR)

  1. SD standard deviation, NR not reported, NA not applicable, VAS visual analog scale, KOOS Knee injury and Osteoarthritis Outcome Score, IKDC International Knee Documentation Committee, T-L Tegner Lysholm Knee Scoring score, SF-12 Short Form Survey score)
  2. a Limited patients at follow up: 6 months, n = 6, 12 months, n = 5, 24 months, n = 1